度洛西汀联合针灸暗示疗法治疗躯体化障碍对照研究

A control study of duloxetine plus acupuncture suggestion ther-apy for somatization disorder

目的：探讨度洛西汀联合针灸暗示疗法治疗躯体化障碍的临床疗效。方法将70例躯体化障碍患者随机分为两组，每组35例，均口服度洛西汀治疗，研究组联合针灸暗示疗法治疗，观察4周。采用症状自评量表和 P300评定临床疗效。结果治疗后两组症状自评量表评分及P300的 N2、P3潜伏期均显著低于治疗前（P ＜0．01），研究组显著低于对照组（P ＜0．01）；P300的N2、P3波幅均显著高于治疗前（P＜0．01），研究组显著高于对照组（P ＜0．01）。研究组有效率97．1％，对照组有效率71．4％，研究组显著高于对照组（P＜0．01）。结论度洛西汀联合针灸暗示疗法治疗躯体化障碍疗效显著，值得临床推广应用。

Objective To explore the efficacy of duloxetine plus acupuncture suggestion therapy （AST ） for somatization disorder （SD） .Methods Seventy SD patients were randomly assigned to two groups of 35 ones each ,both groups took orally duloxetine ,and research group was plus AST for 4 weeks .Efficacies were assessed with the Symptom Checklist‐90 （SCL‐90） and P300 .Results After treatment the SCL‐90 scores as well as P300 N2 and P3 latency of both groups were significantly lower compared with pretreat‐ment （P〈 0 .01） ,so were those in research than in control group （P〈 0 .01） ;N2 and P3 amplitude were significantly higher （P〈 0 .01） ,so were those in research than in control group （P〈 0 .01） .Effective rate was significantly higher in research than in control group （97 .1% vs .71 .4% ,P〈 0 .01） .Conclusion Du‐loxetine plus AST has an evident effect in the treatment of somatization disorder and deserves clinical gen‐eralization and application .