清热通淋丸治疗脊髓损伤并发尿路感染的效果

Effects of Qingretonglin Pill on Urinary Tract Infections after Spinal Cord Injury

目的探讨清热通淋丸联合左氧氟沙星片治疗脊髓损伤并发尿路感染的临床疗效。方法脊髓损伤并发尿路感染患者55例分为对照组(n=27)和观察组(n=28)。对照组服用左氧氟沙星片,每次500 mg,每天1次,共14 d。观察组在对照组基础上服用清热通淋丸,每次1.6 g,每天3次。共14 d。观察两组患者尿频、尿急、尿痛症状的改善时间,给药前后尿白细胞数及尿细菌定量培养的变化情况以及药物不良反应发生率。结果观察组临床有效率(89.3%)高于对照组(63.0%)(P<0.05);尿频、尿急、尿痛症状改善时间短于对照组(P<0.05)。治疗后两组尿白细胞、尿细菌定量培养数均显著减少(P<0.001),且观察组少于对照组(P<0.05)。两组不良反应发生率无显著性差异(P>0.05),但总体较低。结论清热通淋丸联合左氧氟沙星片可改善脊髓损伤并发尿路感染患者临床症状,提高病原菌清除率。

Objective To explore the effect of Qingretonglin pill combined with levofloxacin tablet on urinary tract infection after spinal cord injury.Methods 55 spinal cord injury patients with urinary tract infection were divided into control group（n=27） and observation group（n=28）.Levofloxacin tablets were orally administered in both groups,500 mg everyday,14 days.The Qingretonglin pill was also orally administered in the observation group,1.6 g,3 times every day,14 days.The improvement time of frequent micturition,urgent urination and odynuria,and urinary leukocyte number,urinary bacterial quantitative culture changes and the side effect before and after treatment were observed.Results The effective rate was higher in the observation group（89.3%） than in the control group（63%）（P〈0.05）.The improvement time of frequent micturition,urgent urination and odynuria was shorter in the observation group than in the control group（P〈0.05）.The number of urinary leukocyte and urinary bacterial significantly decreased after treatment（P〈0.001）,and was less in the observation group than in the control group（P〈0.05）.The rate of side effect was low in both groups,and there was no significant difference（P〈0.05）.Conclusion Qingretonglin pill can release the clinical symptoms of urinary tract infection after spinal cord injury,and improve the clearance rate of bacteria.