二氢青蒿素对兔耳增生性瘢痕增生的影响研究

Study the effect of dihydroartemisinin on proliferation of hyperplastic scar in rabbit ears

目的研究二氢青蒿素对兔耳增生性瘢痕增生的影响。方法选取20只成年新西兰大耳白兔建立兔耳增生性瘢痕动物模型,待伤口上皮化后,将其随机分成两组,每组10只。对照组灌胃给予10 m L的生理盐水,实验组灌胃给予10 m L的二氢青蒿素,1次/天,连续给予1周。记录观察术后20 d和50 d 2组兔耳瘢痕的发生和兔耳瘢痕的大小。结果对照组兔耳瘢痕的发生率大于实验组兔耳瘢痕的发生率,差异有统计学意义(P<0.05),表明二氢青蒿素具有降低兔耳瘢痕发生的疗效;对照组兔耳瘢痕大于实验组兔耳瘢痕,差异有统计学意义(P<0.050),表明二氢青蒿素具有治疗兔耳瘢痕的作用。结论二氢青蒿素对兔耳增生性瘢痕具有显著的疗效,作为一种有效的药物,值得对其做进一步的研究。

Objective To study the effect of dihydroartemisinin on proliferation of hyperplastic scar in rabbit ears. Methods 20 New Zealand white rabbits were chosed to establish the models of hyperplastic scar in rabbit ears. The rabbits were randomly divided into two groups after epithelization,10 rabbits in each group. The control group was taken normal saline 10 m L and experimental group was taken dihydroartemisinin 10 m L by intragastric administration,taking once times a day for a week. Happening of rabbits ears scars and size of rabbits ears scars of two groups were recorded and observed 20 ~ 50 days after operation. Results The incidence of rabbits ears scars of control group was higher than that of experimental group,the difference was statistically significant（ P〈0. 05）,which indicated that dihydroartemisinin could reduce rabbits ears scars happening frequencies significantly; Size of rabbits ears scars of control group was bigger than that of experimental group,the difference was statistically significant（ P〈0. 05）,which indicated that dihydroartemisinin had the function of treating rabbits ears scars. Conclusion Dihydroartemisinin has significant curative effects on the treatment of rabbit ears hyperplastic scar,and as a kind of effective drug,it is worthy of further study.