纤维蛋白原在可手术切除非小细胞肺癌中的预后意义

目的探讨可手术切除非小细胞肺癌中纤维蛋白原含量变化与预后的关系。方法选择50例可手术的非小细胞肺癌患者，检测患者术前及术后纤维蛋白原的含量，分析患者的临床特征、生存期与纤维蛋白原含量的关系。结果50例手术根治性切除非小细胞肺癌患者中纤维蛋白原含量升高占40％，与性别、年龄、吸烟状况、组织学分级及临床分期均相关（P〈O．05）。纤维蛋白原升高的无疾病进展时间26．5个月，3年生存率（40．0％）低于纤维蛋白原正常者（56．7％），差异有统计学意义（p〈0．05）。结论可手术切除的非小细胞肺癌患者的预后与纤维蛋白原水平相关。

Objective To explore the relationship between the serum fibrinogen concentration and the clinical prognosis in operable non-small cell lung cancer patients. Methods We retrospectively examined 50 patients who underwent plasma fibrinogen examination before and after operation. The relationship between plasma fibrinogen status and the clinical characteristics, postoperative survival were analyzed retrospectively. Results The total incidence of hyperfibrinogenemia was 40%.Serum fibrinogen concentration was significantly associated with sex, age, smoking behavior, histologic grade, and clinical stage （ P〈0.05 ） . Patients with hyperfibrinogenemia had lower progression-free survival （ 26.5 months ） and three-year overall survival rates （ 40.0% versus 56.7% ） than those with normal serum fibrinogen concentration （ P〈0.05 ） . Conclusion Preoperative serum fibrinogen is closely related to prognostic and survival status in operable NSCLC patients.