肠道微生态与婴儿胆汁淤积性肝病的关系

Relationship of intestinal microecology with infantile cholestatic liver disease

肠道微生态是人体健康所必需的重要且复杂的生物系统,其与肝脏在解剖结构和功能方面均有密切联系。婴儿胆汁淤积性肝病致使胆汁分泌、排泄异常,胆汁排入肠道减少,一方面导致肠道黏膜屏障破坏,肠道微生态改变;另一方面因致病菌、内毒素移位,导致肝损伤,加重胆汁淤积。因此,肠道微生态与婴儿胆汁淤积性肝病联系密切。阐述了肠道微生态与婴儿胆汁淤积性肝病发生发展的关系,认为婴儿发生胆汁淤积性肝病时补充益生菌,有助于促进胆汁排泄,阻断肠道炎症反应,改善患儿预后。推荐常规给予微生态制剂作为治疗和预防婴儿胆汁淤积性肝病的手段。

Intestinal microecology is an important and complex biological system essential to human health. Intestinal microecology and the liver are closely related in anatomical structure and function. Infantile cholestatic liver disease lead to abnormal bile secretion,abnormal excretion,and reduced bile release into the intestinal tract. As a result,the intestinal mucosa barrier is damaged and intestinal microecology changes; at the same time,pathogenic bacteria and endotoxin translocation cause liver injury and aggravate cholestasis. Therefore,a close relationship of intestinal microecology with infantile cholestatic liver disease can be found. In this article,the relationship of intestinal microecology with the development and progression of infantile cholestatic liver disease is illustrated and it is concluded that probiotics should be given as a supplement when infantile cholestatic liver disease occurs,because it promotes bile secretion,blocks intestinal inflammatory reactions,and improves prognosis of the disease. It is recommended to provide microecological agents routinely as a method to prevent and treat infantile cholestatic liver disease.