原发性胆汁性肝硬化的免疫发病机制研究进展

Research progress in immunological mechanisms for primary biliary cirrhosis

原发性胆汁性肝硬化(PBC)是以慢性进行性胆汁淤积为主要特征的自身免疫性肝病,有发展为肝硬化的倾向,其发病机制复杂,病因尚不明确。归纳了近年来PBC的免疫发病机制及相关治疗的最新进展,重点对PBC在自身抗体、免疫细胞及重要的细胞因子与疾病发生相关性等方面作了阐述,指出免疫因素在PBC的发病机制中具有至关重要的作用,认为针对免疫学机制的深入研究可能对于明确PBC的病因以及临床治疗具有重要意义。

Primary biliary cirrhosis（ PBC） is an autoimmune liver disease characterized by chronic and progressive cholestasis,which has a tendency to develop cirrhosis. The pathogenesis of PBC is complicated and still unclear. This paper reviews the latest research progress in immunological mechanisms and therapies for PBC in recent years,which focuses on the relationship between the development of PBC and autoantibodies,immune cells,and important cytokines. The review indicates that immunological factors play a key role in pathogenesis of PBC,and further research on immunological mechanisms might be quite important for the identification of pathogenesis and clinical treatment of PBC.