高迁移率族蛋白B1及内脂素在心肌梗死中的临床意义被引量：3

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摘要目的探讨高迁移率族蛋白B1(HMGB1)及内脂素在心肌梗死中的临床意义。方法回顾性分析就诊于心血管内科的患者85例,分为急性心肌梗死合并心力衰竭(AMHF)组(n=21)、急性心肌梗心功能正常(AMNHF)组(n=31)、陈旧性心肌梗死后心力衰竭(OMHF)组(n=18)及冠状动脉造影正常(NCHD)组(n=15),分析高迁移率族蛋白B1及内脂素与心肌梗死及心力衰竭各项临床指标的关系。结果 4组c Tn I、CK-MBm、NT-pro BNP、CRP、IL-6、HMGB1及内脂素水平比较,差异有统计学意义(P<0.05)。Spearman相关性分析显示,AMHF组血清HMGB1水平与NT-pro BNP及IL-6正相关(P<0.05),内脂素水平与c Tn I及CRP正相关(P<0.05);OMHF组血清HMGB1水平与NT-pro BNP正相关(P<0.05),内脂素水平与NT-pro BNP及CRP正相关(P<0.05);AMHF组及OMHF组血清HMGB1与内脂素水平均呈正相关(P<0.05)。结论 HMGB1及内脂素与心肌梗死后心力衰竭的发生有密切联系,具有广泛的应用价值。

作者武芬芬傅晓敏何昆仑

机构地区中国人民解放军医学院心内科中国人民解放军北京军区总医院保健科中国人民解放军总医院心内科

出处《河北医药》 CAS 2015年第17期2589-2592,共4页 Hebei Medical Journal

关键词高迁移率族蛋白B1 内脂素急性心肌梗死心力衰竭

分类号 R542.22 [医药卫生—心血管疾病]

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