银杏内酯B-西罗莫司药物洗脱支架对猪冠状动脉早期快速内皮化及抗血栓作用

Effect of Ginkgolide B-rapamycin drug-eluting stent system accelerates the early phase re-endothelialization and improves anticoagulation properties in porcine coronary artery

目的明确银杏内酯B-西罗莫司药物洗脱支架(GB-RAP支架)对猪冠状动脉(冠脉)早期快速内皮化及抗血栓的作用。方法将9只小香猪分别制备动静脉分流模型、高负荷血栓模型、球冠状囊损伤模型(每种模型3只),每只猪冠脉内分别置入3种不同的支架(GB-RAP支架、RAP支架、金属裸支架)。通过动静脉分流模型与高负荷血栓模型验证GB-RAP支架的抗血栓作用,通过冠脉球囊损伤模型观察GB-RAP支架对早期内皮化的作用。结果 GB-RAP支架在动静脉分流模型与高负荷血栓模型中较RAP支架与金属裸支架有较好的抗血栓作用,且在猪球囊损伤模型中显示其具有较好的内皮化作用。结论 GB-RAP支架具有良好支架生物相容性,具有早期促进支架内皮化及良好的抗血栓作用。

Objective To clarify the Ginkgolide B-rapamycin drug-eluting stem system in the acceleration of early phase and anticoagulation of porcine coronary artery. Methods 9 pigs were used in this experiment, and 3 pigs were used in each kind of model （ venous shunt model, high load thrombosis model,balloon injury model）, and each pig was put separately in different stent （GB-RAP stent, RAP stent and bare metal stent）. GB-RAP stent＇ s anti thrombosis effect was clarified through the artefiovenous shunt thrombosis model and high load GB-RAP model, the effect of early GB-RAP stent was observed through 1 weeks of porcine coronary artery balloon injury model. Results GB-RAP drug eluting stents has better antithrombotie effect in arteriovenous shunt model and high load thrombosis model than RAP stent and bare metal stent, and it was showed that GB-RAP drug eluting stents has good effect of re-endothel in 1 week after balloon injury in porcine animal model. Conclusion GB-RAP stent has good compatibility with biological scaffolds, and can accelerate the early phase re- endothelialization and improve the anticoagulation property.