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吉西他滨联合方案在治疗淋巴瘤中的疗效观察

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摘要 选取2012年5月~2014年5月间在本院就诊的淋巴瘤患者124例。分为研究组和对照组各60例。研究组患者采用吉西他滨联合奥沙利铂和地塞米松进行治疗。对照组采用培美曲赛进行治疗。在治疗2个周期后进行疗效评价,同时统计患者的不良反应并且在治疗后3个月对患者进行随访。统计治疗效果。结果研究组治疗有效率为54.7%,与对照组的35%相比较差异显著(P〈0.05)。研究组稳定患者比例比对照组多,而研究组患者退步和死亡比例比对照组少,与对照组相比较差异均显著(P〈0.05)。研究组患者出现中性粒细胞减少、血小板减少、发热、恶心呕吐、腹泻和其他不良反应情况具比对照组例数少,与对照组相比较差异均显著(P〈0.05)。研究组患者出现白蛋白降低的例数比对照组相比较差异不显著(P〉0.05)。而研究组患者出现贫血的例数比对照组稍多。吉西他滨联合方案对淋巴瘤具有良好的临床治疗效果。
作者 林志洪
出处 《现代诊断与治疗》 CAS 2015年第13期2951-2952,共2页 Modern Diagnosis and Treatment
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参考文献7

  • 1Zain JM,O'Connor 0.Targeted treatment and new agents in peripheral T-cell lymphoma.Int J Hematol,2010,92(1):33-44.
  • 2Savage KJ,Ferreri AJ,Pileri SA.Peripheral T-cell lymphoma-Not otherwise specified.Crit Rev Oncol Hematol,2011,79(3):321-329.
  • 3万江波,梁辉.外周T细胞淋巴瘤化疗的回顾及进展[J].世界临床药物,2009,30(5):268-271. 被引量:2
  • 4Yao YY,Tang Y,Zou LF.Gemcitabine,oxaliplatin and dexamethasone as salvage treatment for elderly patients with refractory and relapsed peripheral T-cell lymphoma[J].Leuk Lyinphoma,2013,54(6):1194-1200.
  • 5谢剑明,郭晓红,曹梦苒,张军一,罗荣城.GDP方案治疗难治性弥漫大B细胞淋巴瘤的临床研究[J].临床肿瘤学杂志,2010,15(2):150-152. 被引量:5
  • 6赵征,王军,雷宝霞,廖子君.GDP方案治疗复发难治外周T细胞淋巴瘤临床观察[J].现代肿瘤医学,2010,18(11):2233-2234. 被引量:2
  • 7Suyani E,Sucak GT,Yagci M,et al.Gemcitabine and vinorelbine combination is effective in both as a salvage and mobilization regimen in relapsed or refractory Hodgkin lymphoma prior to ASCT[J].Ann Hematol,2011,90(6):685-691.

二级参考文献14

  • 1NCCN非霍奇金淋巴瘤临床实践指南(中国版)专家组.非霍奇金淋巴瘤临床实践指南(中国版)[EB/OL].2007[2008-06-11].http://www.cncc.org.
  • 2Crump M, Baetz T, Couban S, et al. Gemcitabine, dexamethasone, and cisplatin in patients with recurrent or refractory aggressive histology B-cell non-Hodgkin lymphoma: a phase Ⅱ study by the National Cancer Institute of Canada Clinical Trials Group (NCIC-CTG) [J]. Cancer, 2004, 101 (8) : 1835 - 1842.
  • 3Rossi D, Gadano G. Molecular heterogeneity of diffuse large B- cell lympboma: implications for disease management and prognosis[J]. Hematology, 2002, 7(4): 239-252.
  • 4Baetz T, Belch A, Couban S, et al. Gemcitabine, dexamethasone and cisplatin is an active and non-toxic chemotherapy regimen in relapsed or refractory Hodgkinps disease: a phase Ⅱ study by the National Cancer Institute of Canada Clinical Trials Group[J]. Ann Oncol, 2003, 14:1762 - 1767.
  • 5Arkenau HT, Chong G, Cunningham D, et al. Gemcitabine, cisplatin and methylprednisolone for the treatment of patients with peripheral T-cell lymphoma: the Royal Marsden Hospital experience[J]. Haematologica, 2007, 92 (2): 271 -272.
  • 6Julie M.Vose,James Armitage,et al.International peripheral T-cell and natural killer/T-cell lymphoma study:Pathology findings and clinical outcomes[J].J Clin Oncol,2008,26(25):4124-4130.
  • 7Banks PM,Warnke RA.Mature T-cell and NK-cell neoplasms[A].Jaffe ES,Harris NL,Stein H,et al.World Health Organization classification of tumours:Pathology and genetics of tumours of hematopoetic and lymphoid tissues[J].Lyon,France:IARC Press,2001,189-230.
  • 8Rodriguez-Monge EJ,Cabanillas F.Long-term follow-up of platinum-based lymphoma salvage regimens.The MD Anderson Cancer Center experience[J].Hematol Oncol Clin North Am,1997,11:937-947.
  • 9Zinzani PL,Magagnoli M,Bendandi M,et al.Therapy with gemcitabine in pretreated peripheral T-cell lymphoma patients[J].AnnOncol,1998,9:1351-1353.
  • 10PL Zinzani,F Venturini,V Stefoni,et al.Gemcitabine as single agent in pretreated T-cell lymphoma patients:evaluation of the long-term outcome[J].Ann Oncol,2009,5:508.

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