草酸铂治疗上皮性卵巢癌

Treatment of epithelial ovarian cancer with oxaliplatin-based chemotherapy

目的 探讨草酸铂为主的化疗对上皮性卵巢癌的疗效及毒副作用。方法 回顾性分析了2000年5月1日至2002年12月31日收治的39例上皮性卵巢癌使用草酸铂的资料。结果 39例患者中30例可评价疗效,其中初治患者9例,复发患者21例。初治者的近期疗效为PR 88.9％(8/9)。复发患者中铂敏感者的有效率为55.6％(5/9),其中CR 22.3％(2/9),PR 33.3％(3/9);铂耐药者的有效率为PR 16.7％(2/12)。7例有效的复发者中,2例CR患者的无瘤缓解期分别为12个月和15个月,5例PR患者的中位缓解期为4个月。感觉神经毒性的发生率为15.4％(6/39),骨髓抑制23.0％(9/39),肾脏毒性5.1％(2/39),胃肠道反应25.6％(10/39)。结论草酸铂为主的化疗对铂耐药或铂敏感的复发卵巢癌均有一定的疗效;用于卵巢癌的一线化疗亦有较好的近期疗效,其毒性作用一般可耐受。

To investigate the efficacy and toxicity of oxaliplatin-based chemotherapy in the treatment of epithelial ovarian cancer (EOC) . Method The clinical data of 39 cases with EOC having received oxaliplatin based chemotherapy during May. 1,2000 to Dec. 31, 2002 in our hospital were analyzed retrospectively. Results Thirty of 39 cases were eligible for response evaluation, which included 9 untreated cases and 21 recurrences. The response rate for untreated cases was PR 88.9% (8/9); for platinum-sensitive recurrent cases, the overall response rate was 55.6% (5/9) including CR 22.3% (2/9) and PR 33.3% (3/9); for platinum-resistant cases, the response rate was PR 16.7% (2/12) . Of the 7 response cases, the response relapse interval for 2 CR patients was 12 months and 15 months respectively and the median response duration for 5 PR patients was 4 months. The toxicity rate was 15.4% (6/39) for neurosensory toxicity, 23.0% (9/ 39) for myelosuppression, 5.1% (2/39) for nephrotoxicity and 25.6% (10/39) for gastrointestinal reaction. Conclusion oxaliplatin-based chemotherapy is effective both for platinum - sensitive and platinum-resistant recurrent EOC. Good response were also observed in untreated EOC. The toxicity is generally tolerable.