摘要
目的分析软坚散结方联合辛伐他汀治疗颈动脉粥样硬化的临床应用效果。方法选择2012年7月-2014年7月在本院接受住院治疗的颈动脉粥样硬化患者100例作为研究对象,按照随机数字表法将所有入组患者分为观察组（50例）接受软坚散结方联合辛伐他汀治疗,对照组（50例）接受单纯辛伐他汀治疗,比较两组患者的血脂水平、内皮细胞功能、颈动脉IMT及内膜斑块厚度等水平差异。结果观察组患者接受治疗后的TC、TG、LDL水平低于对照组,HDL水平高于对照组患者（P〈0.05）;观察组患者接受治疗后的EMCs水平低于对照组、FMD水平高于对照组患者（P〈0.05）;观察组患者接受治疗后的颈动脉IMT及内膜斑块厚度水平均低于对照组患者（P〈0.05）。结论软坚散结方联合辛伐他汀可以有效降低颈动脉粥样硬化患者血脂水平、颈动脉IMT及内膜斑块厚度,优化内皮细胞功能。
Objective To analyze the clinical application effect of Ruan Jian San Jie Fang combined with simvastatin in the treatment of carotid atherosclerosis. Methods 100 patients with carotid atherosclerosis who were admitted to our hospital and hospitalized from July 2012 to July 2014 were selected as research subjects. They were allocated to observation group and control group with 50 patients in each according to the random number table method. The observation group received the treatment of decoction of herbs aiming at softening hard nodes or masses combined with simvastatin while the control group only received simvastatin. Blood lipid level, endothelial function, carotid IMT, the thickness of intimal plaque, etc of the two groups were compared. Results Levels of TC, TG, LDL after the treatment in the observation group were lower than those in the control group while the level of HDL level after the treatment was higher than that of control group（P〈0.05）; EMCs level after the treatment in the observation group was lower than that in the control group while the FMD level after the treatment was higher than that in the control group; After the treatment, levels of carotid IMT and intimal plaque thickness in the observation group were both lower than those in the control group patients（P〈0.05）. Conclusion Ruan Jian San Jie Fang combined with simvastatin can effectively reduce atherosclerosis blood lipid levels, carotid IMT and intimal plaque thickness of patients with carotid atherosclerosis, and optimize endothelial function.
出处
《中国医药科学》
2015年第16期22-24,29,共4页
China Medicine And Pharmacy
基金
广东省云浮市医学科学技术研究基金项目(2013B39)
