高尿酸血症与急性脑梗死患者病情严重程度和预后的关系

A correlation of hyperuricemia with disease severity and prognosis of patients with acute cerebral infarction

目的探讨高尿酸血症与急性脑梗死患者病情严重程度和预后的相关性。方法选取2013年8月-2014年7月我院收治的100例急性脑梗死患者为研究对象。按照前瞻性病例对照研究方法分析患者入院时、入院后10d的病情严重程度以及90d预后结果与高尿酸血症的相关性。结果急性脑梗死患者入院时的病情严重程度与高尿酸血症无关（P〉0.05）;而10d时的病情严重程度与高尿酸血症显著相关（P〈0.05）;患者入院90d时的预后结果与高尿酸血症显著相关（P〈0.05）。结论高尿酸血症与急性脑梗死患者入院10d后的病情严重程度以及90d后的预后结果存在独立相关性。在急性脑梗死患者发病初期,给予其相应的尿酸治疗对提高该病预后结果有积极的作用。

Objective To explore the correlation between hyperuricemia and disease severity and prognosis of patients with acute cerebral infarction. Methods 100 patients with acute cerebral infarction who were admitted to our hospital from August 2013 to July 2014 were selected as research subjects. The correlations between hyperuricemia and disease severity of patients on admission and 10 days after hospitalization were respectively analyzed and the correlation between hyperuricemia and prognostic results after 90 days was analyzed according to the prospective control research method. Results Disease severity of patients with acute cerebral infarction on admission was irrelative to hyperuricemia（P〈0.05） while disease severity of patients with acute cerebral infarction 10 days after hospitalization was significantly relative to hyperuricemia（P〈0.05）. Prognostic results after 90 days of patients were significantly relative to hyperuricemia（P〈0.05）. Conclusion Hyperuricemia has an independent correlation with disease severity 10 days after hospitalization and prognostic results after 90 days of patients with acute cerebral infarction. In early stage of acute cerebral infarction, a treatment of hyperuricemia has an active effect on the promotion of prognostic result of the disease.