锌α2糖蛋白与胰岛素抵抗相关疾病关系的研究进展

Relationship between zinc-α2-glycoprotein and insulin resistance-related diseases

随着现代生活方式及饮食习惯的改变,疾病谱的重心逐渐转变为慢性非感染性疾病。心血管疾病、糖脂代谢紊乱、肥胖、代谢综合征、多囊卵巢综合征等疾病均与胰岛素抵抗有关。胰岛素抵抗是慢性非感染性疾病的重要组成部分,患病人群众多,严重影响其生活质量。锌α2糖蛋白(Zinc-α2-Glycoprotein,ZAG)是新近发现的一种具有调节体质量和改善胰岛素敏感性的脂肪因子,因其与胰岛素抵抗相关疾病关系密切逐渐受到人们的重视。近年来大量临床实验研究ZAG与胰岛素抵抗的关系,本文拟这些研究进展做一综述。

With the development of modern lifestyle and alteration of eating habits,the core of disease spectrum has gradually turned into chronic non-infectious diseases. Cardiovascular disease,lipid metabolism disorders,obesity,metabolic syndrome,polycystic ovary syndrome are associated with insulin resistance in recent studies. Insulin resistance is an important part of chronic non-infectious diseases,which will seriously influence the quality of life. Zinc-α2-glycoprotein（ZAG） is a newly discovered adipocytokine. Because of its important role of weight controlling and insulin sensitivity improving,lots of clinical studies have been performed to prove the association between ZAG and insulin resistance diseases in recent years.