蛋白质瓜氨酸化及其在类风湿关节炎中的意义

The role of citrullinated proteins in the pathogenesis of rheumatoid arthritis

类风湿关节炎(rheumatoid arthritis,RA)的发病机制至今尚未阐明。RA患者体内发现越来越多的抗瓜氨酸化蛋白抗体(ACPA)提示瓜氨酸化可能参与其发病过程。本文从蛋白质的瓜氨酸化过程、生理功能,ACPA在RA的诊断、预后及发病机制中的作用进行综述,试图更全面地了解蛋白质的瓜氨酸化在RA发病各环节中的作用。

The mechanism of rheumatoid arthritis （RA）has not been clarified. More and more anti-citrullinated protein antibodies （ACPA）have been found in RA patients, suggesting that citrullinated proteins may be involved in the pathogenesis of RA. This paper reviews the process of protein citrullination, physiological function and the role of ACPA in the diagnosis,prognosis and pathogenesis of RA in order to get a more comprehensive understanding of the role of citrullinated proteins in the pathogenesis of RA.