Klotho的研究进展

Research Progress of Klotho

Klotho是新发现的一种抗衰老基因,其表达受多种因素的调控,如活性肽降钙素基因相关肽、成纤维细胞生长因子2等可以上调Klotho表达,而肾素-血管紧张素、尿毒素、炎症反应与氧化应激则可下调Klotho表达。Klotho蛋白有膜结合型和分泌型两种形式。现有研究表明,Klotho参与了多种疾病的发生发展,包括血管钙化、动脉粥样硬化、高血压、肾病损伤、甲状旁腺功能亢进、糖尿病及肿瘤等。本文就Klotho的表达调控及其与疾病的关系简要作一综述。

Klotho,a newly identified anti-aging gene,can be regulated by many factors,such as calcitonin gene-related peptide,fibroblast growth factor 2 could up-regulate Klotho expression; whereas renin-angiotensin system,urinary toxins,inflammation and oxidative stress could reduce expression of Klotho.There are two forms of Klotho protein： membrane-bound Klotho and secreted Klotho. Existing studies showed that Klotho was involved in the development of many diseases,including vascular calcification,atherosclerosis,hypertension,kidney damage,hyperparathyroidism,diabetes and tumors. In this paper,the regulation of Klotho expression and its role in diseases are reviewed briefly.