膀胱癌尿液生物标记物的现状与展望

Present Situation and Prospect of Urinary Biomarkers For Bladder Cancer

膀胱癌是世界上最常见的肿瘤之一,膀胱肿瘤的早期检测对改善病人预后至关重要。目前检测和监视膀胱肿瘤的常规方法是膀胱镜检查联合应用尿细胞学检查,但其局限性已经表明膀胱癌需要更好的诊断方法。理想中的诊断方法应该是非侵袭性的,既能够诊断,也能监测疾病的复发,并且能够为治疗提供依据。因此,以尿液为基础的非侵袭性方法将会给患者和医院带来福音。本文综述了近年来报道的膀胱癌尿液生物标记物及相关新技术。

Bladder cancer is one of the most common cancers in the world. Early detection of bladder cancer is critical to improve the prognosis of the patient. The conventional method for the detection and monitoring of bladder cancer at present is cystoscopy with urinary cytology. Limitations of cystoscopy and urinary cytology have shown the need for better diagnostic method for bladder cancer. Ideally,such assays would be applicable to noninvasively obtained,and be designed not only for diagnosis,but also for monitoring disease recurrence and providing basis for therapy. Consequently,the development of a noninvasive urine-based assay would bring the gospel to both patients and healthcare systems. This article reviews some of the more prominent urine-based biomarkers and related new technologies reported in the literature in recent years.