期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

视黄酸相关孤儿核受体RORα在脂质代谢调控中的作用

下载PDF
导出
摘要 核受体是一类配体依赖的转录因子超家族。视黄酸相关孤儿核受体(retinoid-related orphan nuclear receptors,RORs)由于在基因序列上与视黄酸受体(retinoic acid receptor,RAR)和类维甲酸X受体(retinoid X receptor,RXR)相似而得名。近年来研究陆续发现,核受体RORα不仅在一些代谢组织中表达,而且在脂质代谢,以及动脉粥样硬化的发生发展中扮演关键角色。因此,深入了解RORα与脂质代谢的关系,将为肥胖、2型糖尿病和动脉粥样硬化等疾病提供新的治疗靶点。
作者 林嘉琛 孙艳莎 周博雅 郭译侬 商傅伟 卜军 何奔
机构地区 上海交通大学医学院附属仁济医院心内科
出处 《生理科学进展》 CAS CSCD 北大核心 2015年第4期281-286,共6页 Progress in Physiological Sciences
基金 国家自然科学基金资助项目(81170192 81470389 81270282 813300078 81400261) 教育部新世纪优秀人才支持计划项目(NCET-12-0352) 上海市曙光计划项目(12SG22) 上海交通大学医学院大学生创新实验项目(2014032)资助课题
关键词 核受体 视黄酸相关孤儿受体α 脂质代谢 动脉粥样硬化
分类号 Q756 [生物学—分子生物学]
  • 相关文献

参考文献19

  • 1Kojetin DJ, Burris TP. REV-ERB and ROR nuclear recep- tors as drug targets. Nat Rev Drug Discov, 2014,13 : 197 ~ 216.
  • 2Jetten AM. Retinoid-related orphan receptors (RORs) : crit- ical roles in development, immunity, circadian rhythm, and cellular metabolism. Nucl Recept Signal, 2009, 7 : e003.
  • 3柴文,张宁,王艳青,卜军,何奔.孤儿核受体RORs的病理生理作用及其调控机制[J].生理科学进展,2013,44(2):87-92. 被引量：6
  • 4Burris TP. Nuclear hormone receptors for heme: REV-ER- Balpha and REV-ERBbeta are ligand-regulated components of the mammalian clock. Mol Endocrinol,2008,22 : 1509 - 1520.
  • 5Choi HS, Jean HJ, Lee OH, et al. Indole-3-carbinol, a vegetable phytochemical, inhibits adipogenesis by regulating cell cycle and AMPKo~ signaling. Biochimie, 2014, 104 : 127 ~ 136.
  • 6Lee B, Lee M, Lefevre M, et al. Anthocyanins inhibit lipo- genesis during adipocyte differentiation of 3T3-L1 preadipo- cytes. Plant Foods Hum Nutr, 2014, 69 : 137 ~ 141.
  • 7Kim MB, Song Y, Kim C, et al. Kirenol inhibits adipogene- sis through activation of the Wnt/~-catenin signaling path- way in 3T3-L1 adipocytes. Biochem Biophys Res Commun, 2014, 445 : 433 ~ 438.
  • 8Ohoka N, Kato S, Takahashi Y, et al. The orphan nuclear receptor RORalpha restrains adipoeyte differentiation through a reduction of C/EBPbeta activity and perilipin gene expres- sion. Mol Endoerinol, 2009, 23:759 ~771.
  • 9Bonet ML, Ribot J, Palou A. Lipid metabolism in mammali- an tissues and its control by retinoic acid. Biochim Biophys Acta, 2012, 1821 : 177 ~ 189.
  • 10Kang HS, Angers M, Beak JY, et al. Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism. Physiol Ge- nomics, 2007, 31 : 281 -294.

二级参考文献25

  • 1Fitzsimmons RL, Lau P, Muscat GE. Retinoid-related or- phan receptor alpha and the regulation of lipid homeostasis. J Steroid Biochem Mol Biol,2012,130 : 159 - 168.
  • 2Popov VM, Wang C, Shirley LA, et al. The functional sig- nificance of nuclear receptor acetylation. Steroids ,2007,72 " 221 - 230.
  • 3Wang Y, Kumar N, Solt LA, et al. Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activ- ity by 7-oxygenated sterol ligands. J Biol Chem,2010,285 : 5013 - 5025.
  • 4Solt LA, Griffin PR, Burris TP. Ligand regulation of retinoic acid receptor-related orphan receptors: implications for de- velopment of novel therapeutics. Curt Opin Lipidol,2010, 21 : 204 -211.
  • 5Wang Y, Kumar N, Nuhant P, et al. Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORc- and ROR-. ACS Chem Biol,2010,5 : 1029 - 1034.
  • 6Nishigori M, Nose T, Shimohigashi Y. Highly potent binding and inverse agonist activity of bisphenol A derivatives for ret- inoid-related orphan nuclear receptor ROR-. Toxicol Lett, 2012,212 : 205 -211.
  • 7Jetten AM. Retinoid-related orphan receptors (RORs) : criti- cal roles in development, immunity, circadian rhythm, and cellular metabolism. Nucl Recept Signal ,2009,7 : e003.
  • 8Benderdour M, Fahmi H, Beaudet F, et al. Nuclear receptor retinoid-related orphan receptor cd modulates the metabolic activity of human osteoblasts. J Cell Biochem, 2011,112 : 2160 -2169.
  • 9Srinivas M, Ng L, Liu H, et al. Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta. Mol Endocrinol, 2006,20 : 1728 - 1741.
  • 10Naito T, Shiohara T, Hibi T, et al. 111311 gammat is dispen- sable for the development of intestinal mucosal T cells. Mu- cosal Immunol,2008,3 : 198 - 207.

共引文献5

生理科学进展
2015年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部