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缺氧诱导因子经典通路的拓展与干细胞调控 被引量：1

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摘要 缺氧诱导因子是在缺氧条件下被激活参与机体低氧适应性反应的一类核因子,对于低氧条件下维持机体生命活动起着不可或缺的作用,且与肿瘤的发生发展以及干细胞调控关系密切,本文综述缺氧诱导因子经典氧感通路信号轴和非经典信号通路以及其对干细胞调控的作用,讨论了非经典通路中沉默信息调节因子家族尤其是去乙酰化酶sirtuin-3(SIRT3)对HIFα的负性调控作用,以及M2型丙酮酸激酶(PKM2)对HIFα的激活作用。探讨了HIF1α对多种干细胞生物学的调控,发现HIF1α可抑制胚胎干细胞-外胚层干细胞(ESC-Epi SC)过渡期线粒体呼吸,从而驱使其向糖酵解代谢的转变,继而维持ESC的多能性;且HIF1α可介导间充质干细胞的定向分化,如向成骨细胞,软骨细胞,神经细胞,脂肪细胞,肌细胞等细胞的定向分化;并可促进神经干细胞增殖与迁移以及参与肿瘤干细胞的干性维持。目的阐明缺氧诱导因子经典与非经典信号通路轴及其对干细胞生物学的调控,为临床组织损伤修复组织工程乃至肿瘤的诊疗预防提供新的靶点。
作者 耿书国 刘频健 汪建样 胡文龙 殷明
机构地区 南昌大学第二附属医院 南昌大学研究生院医学部 九江学院
出处 《生理科学进展》 CAS CSCD 北大核心 2015年第4期290-294,共5页 Progress in Physiological Sciences
基金 国家自然科学基金(81160226)资助课题
关键词 缺氧诱导因子 信号通路拓展 干细胞调控 沉默信息调节因子 PKM2
分类号 Q291 [生物学—细胞生物学]
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参考文献19

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二级参考文献31

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生理科学进展
2015年 第4期

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