间充质干细胞在炎症调节中的研究进展

Advances in Mesenchymal Stem Cells in the Regulation of Inflammation

间充质干细胞是一种具有多向分化潜能的成体干细胞,它不仅能促进损伤组织的再生与修复,还拥有良好的免疫调节能力,通过调控免疫细胞的增殖、分化和功能状态,调节炎症因子水平,对于各种炎症相关疾病具有很好的应用前景。该文就间充质干细胞的免疫调节能力的最新进展作一简要阐述,并介绍其在临床前试验的研究结果。

Mesenchymal stem cells are a group of multi-potent adult stem cells. Beside their active effect in tissue regeneration and wound healing, they also show good immune regulatory effect. By regulating proliferation, differentiation, and functional status of immune cells, they can regulate secretion of inflammatory cytokines, showing great potential in inflammation-related diseases. This review aims to briefly summarize the advances for their immunoregulation ability. The application of the mesenchymal stem cells in preclinical trials is also described.