知柏地黄丸联合复方丹参片治疗复发性口腔溃疡的疗效观察

Efficacy Observation of Recurrent Oral Ulceration with Combination of Zhibai Dihuang Pills and Compound Danshen Tablets

目的:观察知柏地黄丸联合复方丹参片治疗复发性口腔溃疡的临床疗效。方法:选取复发性口腔溃疡患者110例,根据用药方案分为对照组和试验组,各55例。对照组患者口服维生素C 0.2 g/次+维生素B210 mg/次+左旋咪唑45 mg/次,均tid,另用西吡氯铵漱口液漱口,15 ml/次,持续1 min,tid;试验组患者口服知柏地黄丸,8丸/次+复方丹参片,3片/次,均tid。10 d为1个疗程,两组患者均治疗2个疗程。观察并比较两组患者疗效、溃疡疼痛视觉模拟评分(VAS)及复发情况。结果:试验组患者的治愈率(80.00%)及总有效率(94.55%)均高于对照组(47.27%、74.55%),差异有统计学意义(P<0.05)。试验组患者治疗3、7 d后的VAS分值均明显低于对照组,差异有统计学意义(P<0.05)。试验组患者治疗2、6、10、12个月后的复发率分别为0、7.27%、9.09%、16.36%,均明显低于对照组(18.18%、34.55%、47.27%、56.36%),差异有统计学意义(P<0.05)。结论:知柏地黄丸联合复方丹参片治疗复发性口腔溃疡,治愈率高,复发率低,疗效确切。

OBJECTIVE：To observe clinical efficacy of recurrent oral ulceration with combination of Zhibai dihuang pills and Compound danshen tablets. METHODS：110 patients with recurrent oral ulceration were selected and divided into control group and trial group with 55 cases in each group. Control group individually received vitamin C 0.2 g/time＋vitamin B210 mg/time＋levamisole 45mg/time,three times a day,Cetylpyridinium chloride collutory,15 ml/time,for 1 min,3 times a day. Trial group received Zhibai dihuang pills orally,8 pills/time,Compound danshen tablets,3 tablets/time,3 times a day. A treatment course lasted for 10 days. Both groups received 2 courses of treatment. Therapeutic efficacy,VAS and relapse were observed and compared between 2 groups. RESULTS：The cure rate（80.00%）and total effective rate（94.55%）of trial group were higher than those of control group（47.27%,74.55%）,with statistical significance（P0.05）. The VAS score of trial group were significantly lower than that of control group after3 and 7 days of treatment,with statistical significance（P0.05）. After 2,6,10 and 12 months of treatment,the recurrence rates of trial group were 0,7.27%,9.09% and 16.36%,which were all significantly lower than those of control group（18.18%,34.55%,47.27%,56.36%）,with statistical significance（P0.05）. CONCLUSIONS：Combination of Zhibai dihuang pills and Compound danshen tablets has definite effect on recurrent oral ulcer,showing high cure rate and not easily recur.