二氧化碳沉淀法去除苯扎贝特中主要杂质

Removal of the Main Impurity from Benzafibrate by a Precipitation Method with Carbon Dioxide

在苯扎贝特合成的后处理过程中,利用苯扎贝特及其主要杂质在酸性上的差异,在反应物的碱性水溶液中通入CO2,将杂质从产物中沉淀去除。以苯扎贝特的收率和含量为指标,对该纯化工艺和传统的重结晶工艺进行了比较。结果显示,该纯化工艺可以使合格品的收率从原工艺的62.5%提高到70.9%。该法克服了常规重结晶带来的大量溶剂消耗和产品损失,有效提高了杂质去除率,降低了分离成本。

According to the acidicity difference between the main impurity and benzafibrate, carbon dioxide was introduced into the alkaline product solution to remove the impurity from benzafibrate in the post-treatment process. The yield and content of the treated products were determined to compare the separation effect with different methods of precipitation and recrystallization. Compared with recrystallization, the yield of the product treated with CO2 was increased from 62.5% to 70.9%. The method not only reduced the relatively large solvent consumption and product loss caused by the repeated recrystallization, but also effectively improved the removal rate of impurities and decreased the separation cost.