载脂蛋白A5基因多态性与代谢综合征的相关性

Association between apolipoprotein A5 genepolymorphism and metabolic syndrome

目的探讨载脂蛋白A5（apoA5）基因-1131T〉C（rs662799）及1259T〉C（rs2266788）单核苷酸多态性与代谢综合征的关系。方法采用聚合酶联反应及限制性片段长度多态性分析方法测定110例代谢综合征（MS）患者及110例健康对照组的apoA5基因-1131T〉C（rs662799）及1259T〉C（rs2266788）二位点的基因型,并检测血糖、血脂等指标,比较不同基因型与MS患病风险的关系。结果 -1131CC基因型携带者体重指数（BMI）、甘油三酯（TG）较TC、CC基因型升高,存在统计学差异（P〈0.05）。1259CC基因型携带者TG、糖化血红蛋白（HBA1C）较TC、CC基因型升高,存在统计学差异（P〈0.05）。-1131CC基因型携带者发生MS的风险是TT基因型携带者的4.5倍（OR=4.504,95%CI：1.766~11.490,P=0.002）,且都得到统计学支持。结论 apoA5-1131T〉C（rs662799）基因多态性与MS的发病可能相关;而apoA5 1259T〉C（rs2266788）基因多态性与MS的发病无明显相关性。

Objective To investigate the relationship between apolipoprotein A5（apoA5）gene and metabolic syndrome（MS）.Methods Polymerase chain reaction and technique of restriction fragment length polymorphism were used to determine the genotypes of apoA5-1131TC（rs662799）and 1259TC（rs2266788）in 110 patients with MS and 110 healthy control subjects.Results The levels of BMI and TG of subjects with apoA5-1131 CC genotype were higher than those of subjects with TC and CC genotype（P〈0.05）.The levels of TG and HBA1 C of subjects with apoA5 1259 CC genotype were higher than those of subjects with TC and CC genotype（P〈0.05）.The risk of MS in subjects with apoA5-1131 CC genotype was 4.5 times higher than that in subjects with TT genotype（OR=4.504,95% CI：1.766-11.490,P=0.002）.Conclusion The genetic polymorphism of apoA5-1131TC（rs662799）may contribute to an increased risk of MS while that of apoA5 1259TC（rs2266788）has no obvious relationship with the occurrence of MS.