四川省藏族僧人高尿酸血症流行病学调查及危险因素分析

Epidemiology Study and Risk Factors Analysis of Hyperuricemia in Tibetan Monks of Sichuan Province

目的 调查四川省藏族僧人高尿酸血症（HUA）患病率并分析其危险因素。方法 选取2014年9~10月四川省甘孜藏族自治州体检的755例18岁以上藏族僧人作为研究对象,并随机选取同时期康定市体检人群作为对照。测量僧人的身高、体质量、腰围、臀围、血压,并测定肝功、肾功、血脂及血常规等,计算不同性别及年龄段僧人的HUA患病率,并与当地城市人群进行对比。同时分析僧人HUA的高危因素。结果 藏族僧人总体血清尿酸（SUA）水平为（318.03±107.70）μmol/L,HUA患病率为21.46%,男性高于女性（25.44%vs.19.02%,P〈0.05）;康定市体检人群HUA总体患病率为30.70%,高于僧人（P〈0.01）;男性僧人HUA患病率低于康定市男性总体检人群（25.44%vs.41.65%）及男性藏族人群（25.44%vs.32.23%,P〈0.01）,而女性僧人则高于康定市女性总体检人群（19.02%vs.14.07%）及藏族女性人群（19.02%vs.14.72%,P〈0.05）;藏族僧人HUA患病率高峰集中在30~40岁之间。Logistic回归分析显示,性别、年龄、腰围、腰高比、空腹血浆血糖（FPG）、血清肌酐（SCr）、血红蛋白（Hb）水平及食用肉类是藏族僧人HUA发生的独立危险因素。结论 男性藏族僧人HUA患病率低于当地城市同性别藏族人群,而女性则相反。性别、腰围、腰高比、FPG、SCr、Hb及食用肉类是藏族僧人HUA发生的独立危险因素。

Objective To investigate the prevalence and risk factors of hyperuricemia （HUA） in Tibetan monks of Sichuan province. Methods 755 adult Tibetan monks （more than 18 years old） in Ganzi Tibetan Autonomous Prefecture of Sichuan Province were included in this study for health examination. Residents of Kangding City who received health examination were selected as controls. We measured the height, body mass, waist circumference, hip circumference, blood pressure and detected liver and renal function, serum lipid and blood routine exam. Then HUA prevalence in different genders and ages, and risk factors of HUA were analyzed. Results The serum uric acid （SUA） level of Tibetan monks was （318.03± 107.70） μmol/L with the total HUA prevalence of 21.46%. The prevalence of male was higher than that of female （25.44% vs. 19.02% ,P〈0.05）. The overall HUA prevalence of residents in Kangding City was 30.70%, which was higher than that of the monks （P〈0.01）. Prevalence of HUA in male monks was lower than the entire male population （25.44% vs. 41.65%） and male Tibetan ones （25.44% vs. 32. 23%） in Kangding city. Among female population, however, we found that the HUA prevalence of monk （19. 02%）was higher than that of overall female population （14. 07%） and Tibetan residents （14.72%） in Kangding （P〈0.05）. Peak prevalence of HUA in Tibetan monks was between 30 and 40 years old. Gender, waist circumference, waist-to-height ratio （WHtR）, fasting plasma glucose （FPG）, serum creatinine （SCr）, hemoglobin （Hb） levels and the consumption of meat were all independent risk factors for the occurrence of HUA in Tibetan monks according to Logistic regression analysis. Conclusion The prevalence of HUA in male Tibetan monks is lower than that of local urban Tibetan population, but the result in female monks is opposite. Gender, waist circumference, WHtR, FPG, SCr, Hb levels and the consumption of meat were all independent risk factors for HUA.