自体富血小板凝胶治疗痛风石合并慢性溃疡的疗效观察

Therapeutic Effect of Autologous Platelet-rich Gel in the Treatment of Chronic Skin Ulcer with Tophus

目的 观察自体富血小板凝胶（autologous platelet-rich gel,APG）治疗痛风石合并皮肤慢性溃疡的有效性和安全性。方法 4例痛风石合并慢性溃疡患者,经过伤口清创,清除坏死组织,刮除痛风石后,给予自体富血小板凝胶治疗。结果 4例患者经自体富血小板治疗（3例患者经过1次APG治疗,1例患者经过2次APG治疗）后,创面在8~22d内均愈合,平均（13.7±6.8）d,没有明显不良反应。结论 采用APG治疗痛风石合并皮肤慢性溃疡,伤口愈合迅速,是一种安全有效的治疗方法。

Objective To evaluate the clinical effectiveness and safety of autologous platelet-rich gel （APG） in the treatment of chronic skin ulcer with tophus. Methods Four patients of chronic skin ulcer with tophus received routine debridement to remove necrotic tissue and erasion tophus as far as possible,and then received the treatment of APG. Results All of the patients had their wounds healed after the treatment of APG （one wound was treated twice）. The wounds were healed between 8 to 22 d, average （13.7±6.8） d, while there were no adverse effects observed. Conclusion Topical therapy with APG may be considered as an effective and safe adjuvant method for the treamtment of chronic skin ulcer with tophus.