血清胱抑素C与血压水平的关系:912例报告

Correlation of serum cystatin C with blood pressure: a cross-sectional study of 912 subjects

目的探讨血清胱抑素C(CysC)与血压水平的关系。方法采用横断面研究方法,从体检人群中随机抽查912例作为研究对象,通过问卷调查及查询体检结果获取一般资料,运用Pearson和多元逐步回归分析血清CysC与血压水平的关系。结果血清CysC水平在正常血压组、高血压前期组及高血压组三组间比较,差别具有统计学差异(P<0.05);Pearson相关分析显示:无论性别,血清CysC水平与收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)、体重指数(BMI)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、尿酸(UA)、尿素(BUN)正相关(P<0.05);以MAP、SBP及DBP为因变量,以血压水平影响因素为自变量的多元逐步回归分析中结果显示:血清CysC对SBP和MAP影响最大(P<0.05),对DBP影响不显著(P>0.05)。结论血清CysC水平对SBP和MAP的影响显著,可以作为预警高血压病的生物标志物。

Objective To study the association between serum cystatin C level and blood pressure. Methods We conducted a cross-sectional study of 912 subjects randomly sampled from a cohort visiting for routine physical examinations. The epidemiological data were obtained using questionnaires and from the database of physical examination results. Pearson analysis and multiple stepwise regression analysis were used to analyze the relationship between blood pressure and cystatin C. Results The levels of serum cystatin C differed significantly among the normotensive, prehypertensive, and hypertensive subjects （P〈0.05）. Pearson analysis revealed that regardless of gender, serum cystatin C was positively correlated with SBP, DBP, MAP, BMI, TC, TG, LDL-C, UA and BUN （P〈0.05）. With MAP, SBP and DBP as dependent variables, multiple stepwise regression analysis of the factors affecting blood pressure indicated that cystatin C had the strongest effect on SBP and MAP （P〈0.05） but did not significantly affect DBP （P〉0.05）. Conclusion Serum cystatin C level is significantly correlated with SBP and MAP and can be used as a biomarker for alert of hypertension.