树突细胞在系统性红斑狼疮的研究进展

Dendritic cells in systemic lupus erythematosus

系统性红斑狼疮是以T细胞过度活化且激活B细胞产生大量自身抗体为特征的自身免疫疾病.研究认为其发病机制受环境与基因的共同调控.树突细胞是目前所知体内功能最强的免疫抗原提呈细胞,在免疫监视、免疫防御和免疫自稳中均发挥作用,是固有免疫和适应性免疫的重要环节.人体血液中两组重要的树突细胞亚群是髓样树突细胞和浆细胞样树突细胞,前者能通过凋亡细胞介导而活化,后者能表达Toll样受体及分泌干扰素α,均在系统性红斑狼疮的发病中起重要作用.此外,树突细胞还通过影响下游免疫反应及微小核糖核酸等转录后调控机制参与系统性红斑狼疮的发病.

Systemic lupus erythematosus （SLE） is an autoimmune disease characterized by the overactivation of T cells and production of plenty of autoantibodies by activated B cells.Recent studies have shown that the pathogenesis of SLE is associated with gene-environment interactions.Dendritic cells （DCs） are known as the strongest antigen-presenting cells in human body,playing an important role in immune surveillance,immune defense and immune homeostasis,and are a key factor in innate and adaptive immunity.Myeloid and plasmacytoid DCs,two major DC subsets in human blood,both play important roles in the pathogenesis of SLE.Myeloid DCs can be activated through the mediation of apoptotic cells,and plasmacytoid DCs can express Toll-like receptors （TLRs） and secrete interferon-α.Moreover,DCs participate in the pathogenesis of SLE by acting on downstream immune responses and post-transcriptional regulations via microRNAs.