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T细胞在寻常型天疱疮发病机制中的作用 被引量：2

Roles of T cells in the pathogenesis of pemphigus vulgaris
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摘要 寻常型天疱疮是一种危及生命的自身免疫性大疱性疾病,以累及皮肤和黏膜为主要症状,临床表现为皮肤黏膜的糜烂、水疱、大疱,组织病理可见表皮内水疱伴棘层松解,是天疱疮中最常见的类型.目前研究达成的共识为寻常型天疱疮的发病除了与抗桥粒芯糖蛋白的IgG抗体介导的体液免疫有关外,T细胞所介导的细胞免疫也是寻常型天疱疮发病的关键因素. Pemphigus vulgaris （PV）,a life-threatening autoimmune bullous disease affecting the skin and mucous membrane,is the most common type of pemphigus.It is characterized clinically by cutaneous and mucosal erosions,blisters and bullae,and histopathologically by intraepidermal blisters and acantholysis.A consensus has been reached that besides anti-desmoglein IgG antibody-mediated humoral immunity,T cell-mediated cellular immunity is also a key factor in the pathogenesis of PV.
作者 戚腾飞 许辉 史玉玲
机构地区 上海市皮肤病医院 同济大学附属第十人民医院皮肤科
出处 《国际皮肤性病学杂志》 2015年第5期319-321,共3页 International Journal of Dermatology and Venereology
基金 国家自然科学基金（81301356） 上海市自然科学基金（13ZR1432200） 上海市科学技术委员会引导项目（134119b0700）
关键词 天疱疮 T淋巴细胞 免疫 CD4阳性T淋巴细胞 CD8阳性T淋巴细胞 T淋巴细胞 调节性 Pemphigus T-lymphocytes Immunity CD4-positive T-lymphocytes CD8-positive T-lymphocytes T-lymphocytes,regulatory
分类号 R758.66 [医药卫生—皮肤病学与性病学]
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参考文献23

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  • 2Tsunoda K, Ota T, Suzuki H, et al. Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigns vulgaris[J]. Eur J Immunol, 2002, 32(3): 627-633.
  • 3Ujiie H, Shimizu H. Evidence for pathogenicity of autoreactive T cells in autoimmune bullous diseases shown by animal disease models[J]. Exp Dermatol, 2012, 21 (12): 901-905.
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二级参考文献34

  • 1程志祥,刘宝瑞.Th1/Th2漂移与肿瘤免疫治疗[J].江苏医药,2006,32(6):567-568. 被引量：12
  • 2肇毅,陆森,成峰,华一兵,吴文溪.Th1和Th2细胞因子在诱导肝肠联合移植免疫耐受中的作用[J].江苏医药,2006,32(10):938-940. 被引量：7
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国际皮肤性病学杂志
2015年 第5期

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