嗜酸性粒细胞相关性皮肤病

Eosinophil-associated dermatoses

嗜酸性粒细胞主要通过抗原抗体反应、释放毒性颗粒、线粒体DNA等介导组织损伤和功能紊乱,嗜酸性粒细胞增多导致的皮损包括,红斑、斑块、结节等,常伴瘙痒.嗜酸性粒细胞增高可表现为外周血嗜酸性粒细胞增高和器官组织嗜酸性粒细胞浸润.外周血及皮损嗜酸性粒细胞均增多的疾病包括,嗜酸性粒细胞增多综合征、变应性肉芽肿性血管炎、木村病、Wells综合征等.外周血嗜酸性粒细胞增多的皮肤病包括,变应性皮肤血管炎、伴嗜酸性粒细胞增多和系统症状的药疹等,皮损处嗜酸性粒细胞增多的皮肤病包括,嗜酸性粒细胞增多性血管淋巴样增生、妊娠类天疱疮、色素失禁症等.

Eosinophils induce tissue damage and organ dysfunction mainly through antigen-antibody reactions,release of toxic granules,mitochondrial DNA,and so on.Skin lesions induced by eosinophilia include erythema,plaques and nodules,usually with itching.Eosinophilia may manifest as an increase of eosinophil count in peripheral blood and eosinophilic infiltration of organs and tissues.Diseases associated with eosinophilia in both peripheral blood and the skin include hypereosinophilic syndrome,Churg-Strauss syndrome,Kimura＇s disease,Wells＇ syndrome,etc.Dermatoses associated with eosinophilia in peripheral blood alone include allergic cutaneous vasculitis,drug reaction with eosinophilia and systemic symptoms,etc,and those associated with eosinophilia in the skin alone include angiolymphoid hyperplasia with eosinophilia,pemphigoid gestationis,incontinentia pigmenti,etc.