摘要
S100A8和S100A9是S100蛋白家族中重要的成员,早期研究认为,S100A8和S100A9参与炎症反应,与机体固有免疫相关,并在调节肿瘤细胞的形成、浸润和转化中起着关键性的作用.然而,近年来研究表明,当机体处于某些特殊条件如伤口愈合、紫外线照射时,上皮细胞也分泌S100A8和S100A9,特别是在一些皮肤病中,这两种蛋白表达都有所上调.随着对S100A8和S100A9与皮肤病关系的进一步研究,可找到对这些疾病新的诊断和治疗方法.
S100A8 and S100A9 are important members of the S100 protein family.It was previously deemed that S100A8 and S100A9 participated in inflammatory reactions,were associated with innate immunity,and played key roles in regulating tumor cell generation,infiltration and transformation.However,recent studies have suggested that when the human body is under some special conditions,such as wound healing and ultraviolet irradiation,epithelial cells are induced to secrete both S100A8 and S100A9 proteins,which are also up-regulated in some dermatoses.With further insight into the relationship between S100A8,S100A9 and dermatoses,new strategies will be developed for the diagnosis and treatment of these entities.
出处
《国际皮肤性病学杂志》
2015年第5期335-338,共4页
International Journal of Dermatology and Venereology
关键词
皮肤疾病
S100蛋白质类
伤口愈合
Skin diseases
S100 proteins
Calgranulin A
Calgranulin B
Wound healing
