人参皂苷Rg_3自微乳化微球的制备及影响因素

Preparation of Microspheres of Self-Microemulsion of Ginsenoside Rg_3 and Analysis of Influence Factors

目的:考察人参皂苷Rg3自乳化微球的制备工艺及影响因素。方法:采用海藻酸钠为药物载体,以人参皂苷Rg3自乳化体系为模型药物,用静电滴制的方法制备人参皂苷Rg3海藻酸钠微球;并考察其外观、重分散性、包封率及影响微球的形成因素。结果:单因素分析、优化载药处方为海藻酸的浓度为1.5%,氯化钡的浓度为30 mmol/L时微球形态呈椭圆形,略有拖尾现象,但分散性好;粒径分布均匀、包封率85.3%。而海藻酸钠、氯化钡溶液的浓度是微球形成的关键因素。结论:用静电滴法制制备的人参皂苷Rg3自微乳化微球方法简单、易行,影响因素可控。

Objective： To investigate the preparation of microspheres of self-microemulsion of ginsenoside Rg3-barium alginate and analyze the influence factors. Methods： Using sodium alginate as the drug carrier and ginsenoside Rg3 as model drug,the method of electrostatic droplet was used to prepare the ginsenoside Rg3-barium alginate microspheres.Observe the appearance,dispersion,encapsulation efficiency and influence factors of microspheres. Results： The microspheres formulation of self-micriemulsion was optimized using single factor analysis and its prescription was alginic acid1. 5% and when barium chloride concentration was 30 mmol/L,microspheres shape was oval,slightly trailing,but good dispersibility and the particle size had uniform distribution and the encapsulation efficiency was 85. 3%. The formation of microspheres was affected by alginic acid and barium chloride concentration. Conclusion： Ginsenoside Rg3-barium alginate by electrostatic drop method is simple and easy and influence factors are controllable.