宫炎平滴丸对慢性盆腔炎免疫状况及细胞因子的影响

Gongyanping Dripping Pill on Immune Status and Cytokine of Chronic Pelvic Inflammatory Disease Patients

目的:研究宫炎平滴丸治疗慢性盆腔炎(湿热瘀结型)的疗效及对患者免疫状况及细胞因子的影响。方法:选择2013年1月—2015年1月慢性盆腔炎(湿热瘀结型)患者88例为研究对象,随机分成两组,每组44例。对照组:采用黄藤素片治疗。观察组:宫炎平滴丸辅助黄藤素片治疗。观察两组患者的体液免疫情况及白细胞介素2(IL-2),白细胞介素10(IL-10),肿瘤坏死因子-α(TNF-α)的变化。结果观察组总有效率84.09%高于对照组总有效率61.36%,差异具有统计学意义(P<0.05)。治疗后,观察组血清Ig G,Ig A,Ig M,C3及C4异常率均少于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组血清Ig G(7.48±1.50)g/L、Ig A(1.65±0.20)g/L、Ig M(1.63±0.11)g/L都低于对照组血清Ig G(8.80±1.55)g/L、Ig A(1.75±0.22)g/L、Ig M(1.69±0.10)g/L,差异具有统计学意义(P<0.01-0.05)。治疗后,观察组血清C3(0.90±0.34)g/L、C4(0.79±0.30)g/L都高于对照组血清C3(0.75±0.32)g/L、C4(0.55±0.27)g/L,差异具有统计学意义(P<0.01-0.05)。治疗后,观察组血清IL-2(4.89±0.74)μg/L,IL-10(75.50±10.25)ng/L都高于对照组血清IL-2(4.21±0.75)μg/L,IL-10(64.45±9.80)ng/L,差异均有统计学意义(P<0.01)。治疗后,观察组血清TNF-α(1.28±0.26)μg/L低于对照组血清TNF-α(1.55±0.25)μg/L,差异具有统计学意义(P<0.01)。结论:宫炎平滴丸治疗慢性盆腔炎(湿热瘀结型)疗效显著,能有效的改善患者的免疫功能。

Objective： To study the effect of Gongyanping dripping pill in the treatment of chronic pelvic inflammatory disease（damp-heat and blood stasis type）,and intervention on the immune status and cytokine. Method： 88 case of chronic pelvic inflammatory disease（damp-heat and blood stasis type） patients during January 2013-January 2015 in our hospital as the research object,were randomly divided into two groups,each group 44 cases. Control group： Huangtengsu Tablets. Observation group： Gongyanping pill and Huangtengsu Tablets. We observed the humoral immune,interleukin 2（IL-2）,interleukin 10（IL-10） and tumor necrosis factor alpha（TNF-alpha） changes in the two groups.Results： The total effective rate of observation group was 84. 09%,higher than 61. 36% in the control group and the difference was statistically significant（P〈 0. 05）. After treatment,serum IgG,IgA,IgM,C3 and the abnormal rate of C4 in the observation group were less than those in the control group and there was statistically significant difference（P〈 0. 05）.After treatment,the serum levels of IgG（7. 48 ± 1. 50） g/L,IgA（1. 65 ± 0. 20） g/L,IgM（1. 63 ± 0. 11） g/L in the observation group were lower than the control group＇s serum levels of IgG（8. 80 ± 1. 55） g/L,IgA（1. 75 ± 0. 22） g/L,IgM（1. 69 ± 0. 10） g/L,with statistically significant difference（P〈 0. 01,P〈 0. 05）. After treatment,the serum levels of C3（0. 90 ± 0. 34） g/L and C4（0. 79 ± 0. 30） g/L in the observation group were higher than the control group＇s serum levels of C3（0. 75 ± 0. 32） g/L and C4（0. 55 ± 0. 27） g/L and there was statistically significant difference（P〈 0. 01,P〈 0. 05）. After treatment,the serum levels of IL-2（4. 89 ± 0. 74） g/L and IL-10（75. 50 ± 10. 25） ng/L in the observation group were higher than the control group＇s serum levels of IL-2（4. 21 ± 0. 75） g/L and IL-10（64. 45 ± 9. 80） ng/L and the differences were statistically significant（P〈 0. 01）. After treatment,the observation group＇s serum TNF-α（1. 28 ± 0. 26） g/L was lower than the control group＇s（1. 55 ± 0. 25） g/L and the difference was statistically significant（P〈 0. 01）. Conclusion： Gongyanping dripping pill in the treatment of chronic pelvic inflammatory disease（damp-heat and blood stasis type） has good curative effect and can improve the immune function effectively.