针灸治疗腰椎间盘突出症临床疗效及对相关指标的影响

Clinical Efficacy of Acupuncture Treatment in Lumbar Disc Herniation and Influence on Serum Inflammatory Factors and Thromboxane B_2

目的:探讨中医针灸治疗腰椎间盘突出症患者临床疗效观察及对血清炎症因子和血浆血栓素B2影响。方法:120例患者按照随机数字表法随机分为两组,分别为对照组和治疗组各60例。对照组采用常规针灸治疗,治疗组采用中医电针治疗。两组均以5 d为1个疗程,连续治疗2个疗程。对比分析两组VAS和PPI评分、疗效、血清IL-6和TNF-α含量变化、血浆血栓素B2含量变化及不良反应发生情况。结果:两组VAS和PPI治疗后较治疗前均显著减少(n<0.05);治疗组VAS和PPI治疗后显著低于对照组(n<0.05);治疗组治疗2个疗程后总有效率(88.33%)显著高于对照组(71.67%),且具有显著性差异(n<0.05);两组血清IL-6、TNF-α含量治疗后较治疗前显著降低(n<0.05);治疗组血清IL-6、TNF-α含量治疗后显著低于对照组(n<0.05);两组血浆血栓素B2含量治疗后较治疗前显著降低(n<0.05);治疗组血浆血栓素B2含量治疗后显著低于对照组(n<0.05);治疗期间均未见明显不良反应发生。结论:中医针灸治疗腰椎间盘突出症患者临床疗效显著,安全可靠,其可能通过降低血清炎症因子和血浆血栓素B2减轻患者疼痛。

Objective： To investigate the clinical efficacy of acupuncture treatment in patients with lumbar disc herniation and the influence on serum inflammatory factors and thromboxane B2. Methods： 120 patients in this trail according to the random number table were randomly divided into two groups,respectively,the control group（n = 60） and the treatment group（n = 60）. Control group was treated with conventional acupuncture. Chinese medicine treatment group received acupuncture treatment. 5 d was a course of treatment for both groups,continuous two courses. We compared the two groups＇ VAS and PPI scores,efficacy,serum IL-6 and TNF-α contents in plasma,thromboxane B2 changes and adverse reactions. Results： The VAS and PPI after treatment were significantly reduced（P 〈0. 05） and those in the treatment group after treatment were significantly lower than those of the control group（P 〈0. 05）. The total efficiency of the treatment group after two courses（88. 33%） was significantly higher than the control group＇s（71. 67%） and there was a significant difference（P 〈0. 05）. Serum levels of IL-6 and TNF-α after treatment were significantly lower（P 〈0. 05）. The treatment group＇s serum IL-6 and TNF-α contents after treatment were significantly lower than those of the control group（P 〈0. 05）. The two groups＇ B2 contents after treatment were significantly decreased（P 〈0. 05） and the treatment group＇s B2 content was significantly lower than that of the control group（P 〈0. 05）. During treatment,there was significant adverse reaction in two groups. Conclusion： The clinical efficacy of acupuncture treatment in patients with lumbar disc herniation is significant,safe and reliable. It may reduce the pain by reducing serum inflammatory cytokines and thromboxane B2.