射频消融联合经肝动脉栓塞化疗对肝癌术后复发患者生存率的影响

Influence of radiofrequency ablation combined with transarterial chemoembolization on the survival rate of recurrented patients with hepatocellular carcinoma

目的探讨射频消融(radiofrequency ablation,RFA)+经肝动脉栓塞化疗(transarterial chemoembolization,TACE)联合治疗较单纯RFA或单纯TACE对肝癌术后复发患者预后生存率的影响。方法原发性肝癌术后有肝内复发而无肝外转移病例83例,按临床给予的治疗方案分为RFA组(A组),TACE组(B组),RFA+TACE联合组(C组),观察各组生存差异。结果 C组中位生存时间最长,(24.0±4.93)个月,B组次之,A组最短。累积生存率曲线显示C组生存率最高。A、B、C三组的0.5、1年生存率差异无统计学意义(P>0.05);2年生存率差异有统计学意义(P=0.041,P=0.030,均<0.05)。结论 RFA+TACE联合治疗较单纯RFA或TACE可以增加肝癌复发患者的2年生存时间,对肝癌术后复发患者是较好的选择。

Objective To dissuss the outcomes of hepatocellular carcinoma （HCC） recurrence patients＇ survival through treatment of RFA＋TACE compared with RFA or TACE alone. Methods The 83 recurrented patients with hepatocellular carcinoma were collected and divided according to clinical treatment regimes into A （RFA） group, B （TACE） group, C （RFA＋TACE） group ; survival difference was observed for each group. Results Group C had the longest median survival time,24.0~4.93 months,followed by group B,finally was group A. Cumulative survival curve showed the highest survival rate in Group C. The three groups of A,B,C 0.5-year,I- year survival rates had no statistically significant difference （P〉0.05）;the 2-year survival rate had significantly higher in group C than in group A,B,with a significant difference （P〈0.05）. Conclusion RFA＋TACE combined therapy can increase the survival time of recurrented patients with HCC compared with RFA or TACE alone.