中药化学成分分析、分离技术及策略

Techniques and strategies for characterization and isolation of chemical components of traditional Chinese medicines

中药的化学成分是其防病、治病的物质基础,中药化学成分的研究是中药现代研究的重要组成部分。由于中药所含化学成分的复杂性,其研究的难度大。近年来随着新型分离材料及方法的应用,以液质联用为代表的分析技术的发展及其配套数据库、软件的开发,中药化学成分的组成表征、定性定量分析、分离纯化等方面都取得很大的进步。本文结合作者的研究实例,对中药化学成分的分析和分离的技术方法、策略及其解决的问题做一简要介绍。

The chemic al composition of traditional Chinese medicine （TCM） is the material base for its prevention and treatment of disease. Characterization, analysis and isolation of chemical constituents, important fields of modern research on TCM, however, are still a great challenge due to the complexity. In recent years, considerable progress has been made in these fields with the application of new chromatographic packing materials and methods, analysis technologies represented by LC-MS and the associated databases and softwares. Here, the advancement of methods and strategies used in the research on the chemical constituents of TCM is briefly reviewed.