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自噬对胰岛β细胞保护作用研究进展 被引量:2

Protective effect of autophagy on pancreatic β cells:research advances
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摘要 糖尿病的发生与胰岛素分泌异常密切相关。胰岛β细胞数量减少或功能缺陷直接影响胰岛素分泌。自噬是一个高度保守的过程,它能改善炎症、氧化应激和内质网应激等对β细胞功能的损伤,延缓糖尿病的病程。本文将从自噬的定义、自噬相关蛋白和信号调节通路、自噬在维持胰岛β细胞结构和功能中的作用,以及影响胰岛β细胞自噬的主要因素等方面进行综述。 The development of diabetes is associated with parasecretion of insulin resulting from the mass loss and dysfunction of β-cell in pancreas. Autophagy is a process of high conservation, which can improve β-cell function impaired by inflammation, oxidative stress, and endoplasmic reticulum stress. That is beneficial to delaying the progression of diabetes. Thus, in this review we summarize the definition of autophagy, autophagy related proteins and modulation of autophagy signaling pathways, the protection of autophagy on the structure and function of β-cells, as well as autophagy in β-cells with inflammation, oxidative stress and endoplasmic reticulum stress.
出处 《国际药学研究杂志》 CAS CSCD 北大核心 2015年第4期447-452,共6页 Journal of International Pharmaceutical Research
基金 国家自然科学基金资助项目(81260502) 云南省应用基础研究联合专项资助项目(2012FB021) 云南省教育厅重点资助项目(2012Z081)
关键词 糖尿病 胰岛Β细胞 自噬信号通路 diabetes mellitus pancreaticβcell autophagy signaling pathway
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  • 1Bhattacharya A, Eissa NT. Autophagy and autoimmunity cross- talks[J ]. Front lmmunol, 2013,4(88) : 1-7.
  • 2Liu Y, Shi S, Gu Z, et al. Impaired autophagic function in rat islets with aging[J]. Age, 2013,35(5) : 1531-1544.
  • 3Hurley JH, Schulman BA. Atomistic autophagy: the structures of cellular self-digestion[J ]. Cell, 2014,157(2) :300-311.
  • 4Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues[J]. Cell, 2011,147(4) :728-741.
  • 5Perluigi M, Di Domenico F, Butterfield DA. mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy [J]. Neurobiol Dis, 2015. doi: 10.1016/j.nbd.2015.03.014.
  • 6Kim YC, Guan KL. mTOR: a pharmacologic target for autophagy regulation[J]. J Clin Invest, 2015,125( 1 ) :25-32.
  • 7Kim J, Kundu M, Viollet B, et al. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulkl [J]. Nat Cell Biol, 2011,13(2) : 132-141.
  • 8Filomeni G, De Zio D, Cecconi F. Oxidative stress and autophagy: the clash between damage and metabolic needs [J]. Cell Death Differ, 2015,22(3 ) : 377-388.
  • 9Watada H, Fujitani Y. Minireview: autophagy in Pancreatic beta-cells and its implication in diabetes [J]. Mol Endocrinol, 2015,29(3) : 338-348.
  • 10Jaber N, Dou Z, Chen JS, et al. Class III PI3K VPS34 plays an essential rule in autophagy and in heart and liver function[J]. Proc Natl Acad Sci USA, 2012,109(6) :2003-2008.

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