不同糖代谢状态冠心病患者氧化应激的研究进展

Research progress of oxidative stress of coronary heart disease patients with different glucose metabolism status

氧化应激水平可以通过抗氧化酶系水平、非酶系抗氧化水平及氧化产物水平检测。在糖尿病前期患者体内存在高氧化应激状态,随着糖代谢紊乱加重,体内自由基生成增加,抗氧化能力下降,氧化应激水平升高,氧化与抗氧化失衡。在2型糖尿病患者中,随着糖尿病的病程延长,氧化应激水平随之升高,且胰岛β细胞功能下降,胰岛素抵抗增加。动脉粥样硬化的发生发展与氧化应激有密切关系,冠心病患者体内已存在氧化应激,且机体抗氧化能力减弱。在冠心病合并糖尿病患者中,随着病情进展,氧化损伤程度呈逐渐加重趋势。本文就不同糖代谢状态冠心病患者氧化应激的相关性研究进展进行综述。

The level of oxidative stress can be tested by antioxidant enzyme system level, antioxidant non-enzyme dsystem level and oxidation products. High oxidative stress state exists in people who have pre-diabetes, and with the sugar metabolic disorder exacerbating, free radicals generation increased, the ability of anti-oxidation dropped, the lev-el of oxidative stress raised, oxidation and antioxidant imbalanced. In patients with type 2 diabetes, with the course of diabetes being longer, the level of oxidative stress will increase, and else the function of the islet beta cell dropped, in-sulin resistance increased. The development of atherosclerosis has deeply related with oxidative stress. There is oxida-tive stress in coronary heart disease patients, and the body＇s antioxidant capacity reduced. In patients with coronary heart disease and diabetes mellitus, as the disease progresses, the degree of oxidative damage also shows a trend of in-crease gradually. In this paper, the research progress of the correlation of oxidative stress of different glucose metabolism status in patients with coronary heart disease will be reviewed.