盐酸胺碘酮注射液与临床常用输液的配伍分析

Analysis the Compatibility of Amiodarone Hydrochloride Injection and Commonly Solution in Clinical

目的分析盐酸胺碘酮注射液与临床常用输液配伍稳定性。方法取盐酸胺碘酮注射液,分别加入0.9%氯化钠注射液、5%葡萄糖注射液和10%果糖注射液中,置于室温下不避光或避光24 h,后使用HPLC法测定不同时间点配伍后溶液药物含量,观察性状、外观,测定p H值。结果 24 h内配伍溶液性状外观无改变,含量及p H值比较稳定。结论盐酸胺碘酮注射液配伍0.9%氯化钠注射液、5%葡萄糖注射液和10%果糖注射液后,稳定性良好。

Objective To analysis the compatibility stability of amiodarone hydrochloride injection and clinical commonly used transfusion.Methods Took amiodarone hydrochloride injection were added into 0.9% sodium chloride injection,5% glucose injection and fructose injection, placed at room temperature for avoiding light or dark 24 hours, after used HPLC determination of compatibility at different time points after drug solution content observed appearance, and pH value is measured.Results There was no change in the appearance, content and pH value of the solution in 24 hours.Conclusion The stability of 0.9% sodium chloride injection, 5% glucose injection and 10% fructose injection is good.