短暂性脑缺血发作患者血清HIF-1α、VEGF的表达及与ABCD2评分的相关性

Expressions of serum HIF-1α and VEGF and their correlation with ABCD2 score in patients with transient ischemica attack

目的观察短暂性脑缺血发作(TIA)患者血清低氧诱导因子-1α(hypoxia-inducible factor-1,HIF-1α)、血管内皮生长因子(vascular endothelial growth factor,VEGF)的表达及其与ABCD2评分间的关系。方法选取72例TIA患者和40例健康对照者;根据ABCD2评分,将TIA患者分为高危亚组(ABCD2>3,n=33)和低危亚组(ABCD2≤3,n=39)。分别检测TIA患者和健康对照者血清HIF-1α、VEGF水平并进行统计学分析。结果与健康人对照组比较,TIA患者血清HIF-1α、VEGF水平明显高于健康对照组。TIA患者中,高危亚组血清HIF-1α、VEGF水平高于低危亚组。相关性分析显示,TIA患者血清HIF-1α、VEGF水平与ABCD2评分呈显著正相关。结论TIA患者血清HIF-1α、VEGF水平升高,与ABCD2评分密切相关。

Objective To detect the expressions of serum hypoxia-inducible factor-1α（ HIF-1α） and vascular endothelial growth factor（ VEGF） in patients with transient ischemia attack（ TIA） and evaluate its correlation with ABCD2 score. Methods Seven-two TIA patients and 30 healthy controls were enrolled in the study. According to ABCD2 scores,TIA patients were divided into two groups,the high-risk group with ABCD2 score 3（ n = 33） and the low-risk group with ABCD2 score≤3（ n = 39）. Serum HIF-1α and VEGF levels in TIA patients and healthy controls were determined and analyzed. Results Compared with healthy controls,serum HIF-1α and VEGF levels in TIA patients increased significantly. In TIA patients the HIF-1α and VEGF levels in the high-risk group were significantly higher than that in the low-risk group.Serum HIF-1α and VEGF levels were significantly positively correlated with the ABCD2 score. Conclusion Increase of serum HIF-1α and VEGF levels in TIA patients is closely related to ABCD2 score.