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肺癌联合治疗方法的重大进展

The optimization of the lung cancer treatment
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摘要 在2014年,随着理解涉及肺癌患者的抗靶向药物逃离信号通路的进展,导致了应对抗靶向药物治疗路径的改进。厄洛替尼治疗,新的联合用药疗法,药物基因组驱动的个性化铂类药物化疗,以及应用PET评估,这些方法的潜在价值代表了另一项关键的重大进展。 With understanding involving the lung cancer resistance to targeted drugs related to escape the signaling pathways,the progress should be lead to the improvement anti-targeted drugs treatment path in 2014. For lung cancer treatment,new combination therapy and chemotherapy drug based on genome-driven personalized platinum drugs,how to manage the potential value of these drugs usage for PET therapy represents another key progress.
作者 鲍文华 杨泽
出处 《中国老年保健医学》 2015年第4期30-33,共4页 Chinese Journal of Geriatric Care
基金 国家自然科学基金(81061120527 81370445 81472408) 卫生部公益性研究基金(201302008) 国家科技部十二五支撑计划(2012BAI10B01)
关键词 非小细胞肺癌 耐药 联合治疗 nonsmall cell lung cancer resistance to targeted drugs combined therapy
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  • 1Sequist LV, Soria JC, Goldman JW, et al. Rociletinib in EGFR-mutated non-small-cell lung cancer [ J]. N Engl J Med, 2015,372 ( 18 ) : 1700 - 1709.
  • 2Pao W,Miller VA, Politi KA, et al. Acquired resistance of lung adeno- carcinomas to gefitinib or erlotinib isassociated witha second mutation in the EGFR kinase domain [ J ]. PLoS Meal,2005,2 ( 3 ) : e73.
  • 3Steuer CE, Khuri FR, Ramalingam SS. The next generation of epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of lung cancer[ J~. Cancer,2015,121 (8) :El -6.
  • 4DeSantis C, Naishadham D, Jemal A. Cancer statistics for African Amer- icans,2013[ J~. CA Cancer J Clin,2013,63(3) : 151 - 166.
  • 5Jorge SE, Kobayashi SS, Costa DB. Epidermal growth factor receptor (EGFR) mutations in lung cancer: preclinical and clinical data[ J]. Braz J Med Biol Res,2014,47 ( 11 ) :929 - 939.
  • 6Jemal A, Bray F, Center MM, et al. Global cancer statistics [ J ]. CA Cancer J Clin,2011,61 (2) : 69 -90.
  • 7Jorge SE, Kobayashi SS, Costa DB. Epidermal growth factor receptor (EGFR) mutations in lung cancer: preelinical and clinical data[J]. Braz J Med Biol Res,2014 Sep 5 ;0:0. [ Epub ahead of print].
  • 8PubMed PMID : 25211582. Jackman D, Pao W, Riely GJ, et ai. Clinical definition of acquired re- sistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer[ J]. J Clin Onco1,2010,28 ( 2 ) : 357 - 360.
  • 9Waiter AO,Sjin RT,Haringsma HJ, et al. Discovery of a mutant-selec- tive covalent inhibitor of EGFR that overcomes T 790M-mediated resist- ance in NSCLC [ J ]. Cancer Discov ,2013,3 ( 12 ) : 1404 - 1415.
  • 10Rosell R, Bivona T. G, Karachaliou N. Genetics and biomarkers inpersonalisation of lung cancer treatment[ J ]. Lancet ,2013,382:720 - 731.

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