同型半胱氨酸与肺动脉高压的相关性研究

Correlation between chronic obstructive pulmonary disease caused by pulmonary hypertension and homocysteine

肺动脉高压是慢性阻塞性肺疾病的主要并发症之一,可由多种因素综合作用产生,其中低氧相关性和慢性血栓栓塞是重要的两个原因。其临床症状不典型,故早期往往被漏诊,严重影响疾病的及时治疗和预后。同型半胱氨酸(homocysteine,Hcy)参与临床很多疾病的发生发展,国内外对其与疾病的相关性研究很受关注,COPD所致肺动脉高压也毫无例外的与Hcy有密切相关性。深入认识肺动脉高压与Hcy相关性研究,有助于对肺动脉高压患者的治疗、预防,对改善患者预后和提高生活质量、降低病死率有重大意义。

Pulmonary hypertension is a major complication of chronic obstructive pulmonary disease,by various factors lead,hypoxiarelated and chronic thromboembolic are two important reasons. Its clinical Symptoms are not typical,it often disproportionately affect the treatment and prognosis of the diseases,because of misdiagnosis and missed diagnosis in the eary. Hcy involved in the formation of many diseases in clinical,its correlation study is concerned about by domestic and international doublly. Indepth understanding of advances in pathogenesis and treatment can contribute to the prevention of its early,aggressive treatment,to improve the prognosis and quality of life and reduce mortality is significant.