参芎葡萄糖注射液对不稳定型心绞痛心功能、血脂及炎症因子的影响

Influence of Shenxiong Glucose Injection on Heart Function,Blood Lipid and Inflammatory Factors in Patients with Unstable Angina

目的:观察参芎葡萄糖注射液对不稳定型心绞痛的心功能、血脂及炎症因子的影响。方法:随机将2012年6月—2014年5月在我院治疗的70例不稳定型心绞痛患者分为两组,对照组(35例)采用常规治疗方法,包括控制血压和血糖、抗血小板聚集和抗凝等治疗,在对照组的基础上,治疗组(35例)给予参芎葡萄糖注射液静脉滴注,100 m L/次,1次/d,共治疗3周。观察对比两组治疗前后的西雅图心绞痛调查量表(SAQ)评分、心功能、血脂、高敏C反应蛋白(hs-CRP)及肿瘤坏死因子-α(TNF-α)变化,并对比两组治疗过程中的主要不良心脏事件及不良反应发生情况。结果:治疗前,两组的SAQ评分、心功能参数、TG、CHO、HDL-C、LDL-C、hs-CRP和TNF-α均无显著性差异(P>0.05)。治疗后:(1)两组的SAQ评分均有明显的改善(P<0.05),且在SAQ评分中疾病认知程度对比中,两组无显著性差异,在其他的指标中,治疗组均优于对照组(P<0.05)。(2)两组治疗后的心功能参数均有明显的改善(P<0.05),且治疗组的改善程度均优于对照组(P<0.05)。(3)两组治疗后的TG、CHO、HDL-C、LDL-C均得到一定的改善(P<0.05)。治疗组治疗后的TG、CHO、LDL-C均低于对照组(P<0.05),而两组治疗后的HDL-C无明显差异(P>0.05)。(4)两组治疗后的hs-CRP和TNF-α显著性下降(P<0.05)。治疗组治疗后的hs-CRP和TNF-α均明显低于对照组(P<0.05)。在整个治疗过程中,两组累计心血管事件发生率无明显差异(P>0.05);两组均未发生不良反应,无显著性差异(P>0.05)。结论:参芎葡萄糖注射液辅助治疗不稳定型心绞痛疗效较佳,能有效地改善心功能,调节血脂代谢,抑制炎症反应。

Objective：To observe the influence of Shenxiong Glucose Injection on heart function,blood lipid and inflammatory factors in patients with unstable angina. Method：70 patients with unstable angina in our hospital from June 2012 to May 2014 were divided randomly into two groups,control group（35 cases）was gave conventional treatment which include the control of blood pressure and blood sugar,antiplatelet aggregation and anticoagulation therapy,on the basis of the control group,the treatment group（35 cases）were gave Shenxiong Glucose Injection for intravenous drip,100 m L each time,one time each day,total treatment for 3 weeks. Changes of Seattle angina questionnaire（SAQ）score,cardiac function,blood lipids,high-sensitivity c-reactive protein（hs-CRP）and tumor necrosis factor alpha（TNF alpha）before and after treatment were observed and compared between the two groups,and major adverse cardiac events and adverse reactions in the process of treatment were compared. Results：Before the treatment,SAQ scores,cardiac function parameters,TG,CHO,HDL,LDL- C- C,hs-CRP and TNF-alpha had no significant difference from the two groups（P〉0.05）. After treatment：（1）the SAQ scores of the two groups were improved significantly（P〈0.05）,and the degree of disease cognition in the SAQ scores,there was no significant difference from two groups,in other indicators,the treatment group were better than control group（P〈0.05）.（2）the cardiac function parameters of the two groups after treatment were significantly improved（P〈0.05）,and the improve degree of treatment group were better than that of control group（P〈0.05）.（3）TG,CHO,HDL- C,LDL-C after treatment in the two groups also had certain improved（P〈0.05）. TG,CHO,LDL-C after treatment in the treatment group were lower than that in control group（P〈0.05）,while HDL-C of two groups after treatment had no obvious difference（P〈0.05）.（4）the hs-CRP and TNF alpha after treatment in the two groups significantly decreased（P〉0.05）. the hs-CRP and TNF alpha after treatment of treatment group were significantly lower than that of control group（P〉0.05）. In the process of the treatment,the cumulative incidence of cardiovascular events in two groups had no obvious difference（P〉0.05）;The two groups had no adverse reactions,with no significant difference（P〉0.05）. Conclusion：The curative effect of Shenxiong Glucose Injection in treatment of patients with unstable angina is good,can effectively improve cardiac function,regulate lipid metabolism,refrain the inflammatory response.