棓丙酯治疗急性心肌梗死疗效观察

Curative Effect Observation of Propyl Gallate Injection in the Treatment of Patients with Acute Myocardial Infarction

目的:观察丙酯注射液治疗接受直接经皮冠状动脉介入治疗(PCI)后的急性心肌梗死患者的临床疗效,探讨应用丙酯注射液是否减少不良心脏事件的发生及药物本身的安全性。方法:纳入78例诊断为急性ST段抬高型心肌梗死并行急诊PCI的患者,随机分为观察组与对照组(观察组43例,对照组35例)。所有患者术前给予常规处置及治疗,观察组于术后应用丙酯注射液120 mg,加入0.9%氯化钠溶液250 m L静脉点滴,1 d 1次,疗程为10 d。术前及术后24 h检查心肌损伤标志物肌钙蛋白T,于术前、术后24 h、术后2 d及出院前检测血清磷酸肌酸激酶同工酶CK-MB的指标,主要观察直接PCI后的患者应用丙酯注射液治疗后的疗效。随访期为6个月,记录患者在术后当日至术后6个月期间不良心脏事件的发生率(包括全因死亡、非致死性心肌梗死、靶血管再次血运重建)及出血等并发症。结果:急性ST段抬高型心肌梗死患者急诊PCI后心肌损伤标志物均有不同程度的升高(P<0.01)。应用丙酯注射液治疗的患者临床疗效显效性优于对照组(P<0.05)。对照组死亡1例,观察组非致死性心肌梗死1例,两组患者半年内无出血等不良反应的发生,两组相比差异无统计学意义(P>0.05)。结论:丙酯治疗急诊心肌梗死患者安全有效。

Objective：To observe the clinical effect of propyl gallate injection in the treatment of patients with acute myocardial infarction.This study discusses whether the application of propyl gallate injection can reduce adverse cardiac events and other adverse reactions,and investigate the safety of propyl gallate. Method：A total of 78 patients with acute myocardial infarction were randomly divided into two group（the study group：n=43;the control group：n=35）.All patients were given conventional treatment before PCI.The study group in postoperative was applied of propyl gallate injection 120 mg＋0.9% Sodium Chloride Solution 250 m L,intravenous drip,once a day（QD）,10 days for a course. Before PCI,24 h after PCI,the levels of cardiac markers-cardiac troponin T were detected. Levels of cardiac markers-creatine kinase-MB were determined before the treatment,24 h after operation,2 days after the operation and before discharge.The main outcome PCI postoperative propyl gallate injection therapy enhanced the efficacy.Patients were followed up for six months,records of the patients in the postoperative adverse cardiac events during the day to half a year（including the incidence of all-cause mortality,nonfatal myocardial infarction,target vessel revascularization）and hemorrhage. Results：Myocardial injury markers was increased with the emergency treatment of acute myocardial infarction after PCI.The clinical effect of patients with application of propyl gallate injection was better than that of control group（P〈0.01）.The control group has one cases of death,the study group has one patient who died of nonfatal myocardial infarction（P〈0.05）.No adverse reactions such as bleeding of the two groups of patients within six months（P〉0.05）.Conclusion：Propyl gallate treatment in patients with acute myocardial infarction was effective and safety.