茵栀黄汤对新生儿黄疸血清总胆汁酸浓度变化影响

Effect of Yinzhihuang Decoction on Changes of Serum Total Bile Acid Concentration of Neonatal Jaundice

目的:探讨茵栀黄汤对新生儿黄疸血清总胆汁酸浓度变化影响效果。方法:选取我院儿科收治的新生儿黄疸患儿60例,随机分为两组,其中对照组30例,予常规西医对症治疗,抗感染、纠正酸碱、离子平衡,补液、吸氧等,并给予苯巴比妥5 mg/(kg·d),尼可刹米0.25 g,日1次口服。1周为1疗程,治疗2个疗程。实验组30例,在对照组常规对症治疗基础上,予茵栀黄汤(茵陈10 g,栀子5 g,茯苓10 g,黄芪10 g,大黄5 g,车前草5 g,黄柏5 g,甘草10 g),日1剂水煎早晚分服,1周为1个疗程,治疗2个疗程。治疗结束后,对比各组患儿黄疸及大便状态改变情况、肝功及血清总胆汁酸、胆红素水平改变情况。结果:1试验后各组黄疸及大便性质均在短时间改善,实验组黄疸消退、便质、便次、便色恢复较对照组改善明显,差异有统计学意义(P<0.05);2试验后各组肝功能均有不同程度变化,实验组AST、ALP、GGT较对照组改善明显,差异有统计学意义(P<0.05);3试验结束后,各组血清总胆汁酸、胆红素均不同程度改善,实验组TBA、TBA、TBIL、DBIL较对照组改善明显,差异有统计学意义(P<0.05)。结论:茵栀黄汤对黄疸患儿可改善肝功能,改善消化道功能,促进大便性状、颜色恢复正常,减少排便次数,提高患儿对营养吸收效率,对临床具有指导意义。

Objective：To investigate the effect of Yinzhihuang Decoction on changes of serum total bile acid concentration of neonatal jaundice. Methods：60 cases of neonatal jaundice,were randomly divided into two groups,30 cases in the control group,treated with conventional western medicine symptomatic treatment.The experimental group and 30 cases in the control group,the basis of conventional symptomatic treatment,to Yinzhihuang Decoction（Yinchen 10 g,astragalus 5 g,poria 10 g,fructus 10 g,rhubarb 5 g,phellodendron 5 g,plantain 5 g,licorice 10 g）,twice a day,1 weeks for 1 courses,2 courses of treatment. After the end of treatment,compared with jaundice and stool state changes,liver function and the serum total bile acid,bilirubin level change. Results：Compared with the control group,the experimental group jaundice subsided time,bowel recovery,stool frequency,then color restoration degree recovered better,P〈0.05;Compared with the control group,the experimental group AST,ALP,GGT improved significantly,P〈0.05;total bile acid and bilirubin in serum,have different degrees of improvement,the experimental group TBA,TBA,TBIL,DBIL decreased significantly than the control group,P〈0.05. Conclusion：YinzhihuangDecoction for jaundice can improve liver function,improve the gastrointestinal function,promote the stool,color returned to normal,reduce the frequency of defecation,improve the absorption efficiency of children nutrition,has the guiding sense to the clinical.