丹红注射液对不稳定型心绞痛患者血清炎症因子及血管内皮功能的影响研究

Effects of Danhong Injection on Unstable Factors and Vascular Endothelial Function of Inflammation in Patients with Angina Pectoris

目的:探讨丹红注射液对不稳定型心绞痛患者血清炎症因子和血管内皮功能的影响。方法:选取2013年2月—2014年2月在我院就诊的不稳定型心绞痛患者108例,随机分为观察组和对照组,每组54例。对照组患者采用常规治疗方案:给予他汀类药物、硝酸酯类、低分子肝素和钙离子拮抗剂等,观察组在此基础上增加使用丹红注射液。治疗2周后比较两组血清炎症因子和反映血管内皮功能相关因子的变化及临床疗效。结果:观察组和对照组治疗后hs-CRP和TNF-α与相应组别治疗前比较,P<0.05,差异具有统计学意义,但观察组hs-CRP和TNF-α治疗后降低幅度超过对照组(P<0.05);观察组和对照组治疗后FMD、ET和NO与相应组别治疗前比较,P<0.05,差异具有统计学意义,但观察组FMD和NO升高的幅度,ET降低的幅度超过对照组(P<0.05);观察组患者临床总有效率(94.44%)与对照组(74.07%)比较,P<0.05,差异具有统计学意义。结论:丹红注射液对不稳定型心绞痛患者炎症因子和血管内皮功能具有调节改善作用,提高临床疗效,值得推广。

Objective：To investigate the effect of Danhong Injection on unstable angina pectoris serum inflammatory factors and endothelial function. Methods：From 2013 February-2014 year in February in 108 cases of patients with unstable angina pectoris in our hospital,were randomly divided into observation group and control group,54 cases in each group. The control group was treated with conventional treatment plan：statins,nitrate,low molecular weight heparin and calcium antagonists,on the basis of the observation group to increase the use of Danhong injection. Changes in treatment were compared between the two groups of serum inflammatory factors and reflect the vascular endothelial function related factors and clinical efficacy after 2 weeks. Results：Compared to the observation group and the control group after treatment hs-CRP and TNF- alpha and the corresponding groups before treatment,P〈0.05,with statistically significant difference,but the observation group after treatment hs-CRP and TNF- alpha reduces by more than the control group（P〈0.05）;compare the observation group and control group after treatment,FMD,ET and NO and the corresponding group before treatment,P〈0.05,statistically significant differences were observed in group FMD and NO,but the increasing amplitude,the magnitude of ET lowering than the control group（P〈0.05）;patients in the observation group the total clinical effective rate（94.44%）and the control group（74.07%）compared to,P〈0.05,with significant difference. Conclusion：Danhong injection has a moderating effect on improvement of unstable angina patients with inflammatory cytokines and vascular endothelial function,improve clinical efficacy,is worthy of promotion.