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肝细胞生长因子的分子生物学研究 被引量：7

Molecular Biological Progress of Hepatocyte Growth Factor (HGF)
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摘要 肝细胞生长因子 (HGF)是一种多功能细胞因子 ,其分子为异二聚体糖蛋白 ,有NK1,NK2 ,NK4三个变种。HGF启动子的结构很复杂 ,其表达受多种因素和调控元件的调节。因HGF在体内有重要作用 。 Hepatocyte growth factor (HGF) is a multifunctional growth factor which is a heterodimeric glycoprotein molecule. There are three truncated HGF variants:NK1,NK2,NK4.The structure of the promoter of HGF is very complicated, and the expression of HGF is regulated by various factors and regulatory elements. Because of the importance of HGF to human body, the genetic engineering expression and gene therapy investigation of HGF are being done.
作者 俞水亮 杨复华
机构地区 武汉大学生命科学院
出处 《生物工程学报》 CAS CSCD 北大核心 2002年第1期1-4,共4页 Chinese Journal of Biotechnology
关键词 肝细胞生长因子 分子生物学研究 HGF 基因表达 基因工程 hepatocyte growth factor (HGF), gene expression, genetic engineering
分类号 Q71 [生物学—分子生物学] TQ460.38 [化学工程—制药化工]
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参考文献19

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  • 3[3]Jakubezak J L, Lakochelle W J, Merlino G. NK1, a natural splicevariant of hepatocyte growth factor/scatter factor, is a partial agonistin vivo . Mol Cell Biol , 1998,18:1275 ～ 1283
  • 4[4]Otsuka T, Jakubczak J, Merlino G et al. Disassociation of Met-med-iated biological responses in vivo: the natural hepatocyte growth far-tor/scatter factor splice variant NK2 antagonizes growth but facilitatesmetastasis. Mol Cell Biol, 2000,20: 2055 ～ 2065
  • 5[5]Date K, Matsumoto K, Nakamura T et al. Inhibition of tumor growthand invasion by a four-Kringle antagonist (HGF/NK4) for hepatocytegrowth factor. Oncegene, 1998,17: 3045 ～ 3054
  • 6[6]Parr C, Hiscox S, Nakamura T et al. NK4, a new HGF/SF variant,is an antagonist to the influence of HGF/SF on the motility and inva-sion of colon cancer cells. Int J Cancer ,2000,85:563 ～ 570
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生物工程学报
2002年 第1期

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