以土家医三元论为指导的反选法在新药研究中的应用

Application of backward selection method based on Tujia medical trialistic theory in new drug research

根据土家医三元论中"药性、物质、功效"三元性提出的反选法,即是以常用的由功效到物质或由物质到功效的单向思维及研究方式为基础,利用传统药物多成分、多靶点优势,形成的由功效到功效或由物质到物质的双向/多向思维和研究方式。利用反选法以已知功效为起点,通过成分分析,发现另一种与已知功效相关联的新作用,从而发现传统药物新功效或更安全的用法;或者以已知物质成分为起点,通过成分分析,发现与已知功效相反的新成分,从而指导药物炮制或发现新药物资源与新药。反选法是一种简捷有效的研究方法,可以更好地利用传统药物多成分、多靶点优势,促进传统药物的合理使用及新药研发。

Based on the trialistic theory of drug properties,substances,and efficacy in Tujia medicine,We adopted the one-way thinking and research method from efficacy to substance or vice versa and utilized the multicomponent and multi-target advantage of traditional medicine.At last,we had developed the bidirectional or multidirectional thinking and research method from efficacy to efficacy or from substance to substance.In the study,we used the backward selection method based on the known effects of current drug to fine another new role with known efficacy related by analyzing components,so as to find new efficacy or safer usage;We used the known substances as a starting points to find the new chemicals with the function compared to the known efficacy,thus the drug processing will be guided and the new medicinal resources and drugs will be found.The backward selection method is a simple and effective research method,which might make better use of traditional medicinal components and advantages of drug multi-target,and promote the rational use of traditional medicine and the research and development of new drugs.