虎杖花的化学成分研究

Chemical constituents in flowers of Polygonum cuspidatum

目的研究虎杖Polygonum cuspidatum花的化学成分。方法利用溶剂提取、硅胶柱色谱和Sephadex LH-20反复进行分离纯化,根据波谱数据和理化性质鉴定化合物结构。结果从虎杖花甲醇提取物的乙醚、甲醇萃取部分分离得到16个化合物,分别鉴定为β-谷甾醇(1)、芦荟大黄素(2)、大黄素甲醚(3)、大黄素(4)、胡萝卜苷(5)、大黄酚(6)、槲皮素(7)、山柰酚(8)、蒽醌苷B(9)、大黄酸(10)、芹菜素(11)、橙皮素(12)、4-羟基苯乙酮(13)、芦丁(14)、蔗糖(15)、染料木素(16)。结论化合物2、8、12、13、15、16为首次从虎杖花中分离得到。

Objective To investigate the chemical constituents in the flowers of Polygonum cuspidatum.Methods The components were separated by means of solvent extraction,repeated chromatography with silica and Sephadex LH-20 column.The structures were determined by spectral analysis and physicochemical properties.Results Sixteen compounds were isolated from the ethyl ether extract and methanol extract from the flowers of P.cuspidatum and identified as β-sitosterol（1）,aloe-emodin（2）,physcion（3）,emodin（4）,daucosterol（5）,chrysophanol（6）,luteolin（7）,kaempferol（8）,anthraglycoside B（9）,rhein（10）,apigenin（11）,hesperetin（12）,4-hydroxyacetophenone（13）,rutin（14）,sucrose（15）,and genistein（16）.Conclusion Compounds 2,8,12,13,15,and 16 are obtained from the flowers of P.cuspidatum for the first time.