VDR基因FokI多态性与原发性肝癌遗传易感性的关系研究被引量：1

STUDY ON RELATIONSHIPS BETWEEN FOK I SITE POLYMORPHISM OF VDR GENE AND HEREDITARY SUSCEPTIBILITY OF PRIMARY HEPATIC CARCINOMA

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摘要目的:探讨维生素D受体(VDR)基因Fok I位点多态性与原发性肝癌遗传易感性的关系。方法:采用聚合酶链限制性片段长度多态性分析和基因测序技术,对105例原发性肝癌患者和100例健康体检者VDR基因Fok I位点的多态性进行分析。结果:原发性肝癌患者Fok I位点ff基因型频率明显高于健康体检者。与FF基因型相比,ff基因型患原发性肝癌的风险性增加(OR=2.241,P<0.05);与F等位基因相比,携带f等位基因的个体更易罹患原发性肝癌(OR=1.479,P<0.05)。结论:VDR基因Fok I位点多态性可能是原发性肝癌发生的遗传易感因素之一。 Objective： To investigate the relationships between Fok I site polymorphism of vitamin D receptor（VDR） and hereditary susceptibility of primary hepatic carcinoma. Methods： Polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） and genetic sequencing technology were used to detect polymorphisms of VDR gene Fok I site polymorphism of 105 primary hepatic carcinoma patients and 100 healthy controls. Results： The Fok I site ff genotype frequency of primary hepatic carcinoma patients was obviously higher than healthy controls. Compared with FF genotype, the ff genotype increased the risk of suffering primary hepatic carcinoma（OR=2.241, P〈0.05）. Compared with F allele, the individuals carrying f alleles were more prone to primary hepatic carcinoma（OR=1.479, P〈0.05）. Conclusions： The VDR gene Fok I site polymorphism maybe one of the genetic susceptibility factors of primary hepatic carcinoma.

作者刘强潘光栋郑敏

机构地区广西科技大学附属柳州市人民医院肝胆外科柳州市妇幼保健院儿内分泌科

出处《承德医学院学报》 2015年第5期369-371,共3页 Journal of Chengde Medical University

基金广西壮族自治区卫生厅科研自筹课题基金资助项目(Z2014418)

关键词维生素D受体基因多态性原发性肝癌遗传易感性 Vitamin D receptor Gene polymorphism Primary hepatic carcinoma Hereditary susceptibility

分类号 R735.7 [医药卫生—肿瘤]

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