摘要
目的:研究5%盐酸普萘洛尔乳剂造模周期对豚鼠银屑病模型的影响。方法:5%盐酸普萘洛尔乳剂涂抹豚鼠耳部分别造模14d、21d和28d,测量豚鼠耳部表皮厚度,HE染色观察豚鼠耳部皮肤形态结构的变化。结果:随着5%盐酸普萘洛尔乳剂造模时间的延长,豚鼠耳部表皮厚度逐渐增加,耳部皮肤的病理变化逐渐加重。结论:5%盐酸普萘洛尔乳剂诱发豚鼠银屑病模型的严重程度为造模28d>造模21d>造模14d。
Objective： To study the effects of 5% propranolol hydrochloride emulsion molding period on guinea pig models of psoriasis. Methods： The guinea pig models of psoriasis were made by applying 5% propranolol hydrochloride emulsion to the ear of guinea pig respectively for 14 d, 21 d, and 28 d. The epidermal thickness of guinea pig＇s ear was measured; HE stain was used to observe the morphological changes of guinea pig＇s ear skin. Results： Along with modeling time extension, the epidermal thickness of guinea pig＇s ear increased gradually, the pathological changes of guinea pig＇s ear skin aggravated gradually. Conclusions： The severity that 5% propranolol hydrochloride emulsion induced guinea pig models of psoriasis is modeling time 28d〉21d〉14d.
出处
《承德医学院学报》
2015年第5期374-376,共3页
Journal of Chengde Medical University
关键词
银屑病
盐酸普萘洛尔
造模周期
动物实验
Psoriasis
Propranolol hydrochloride
Molding period
Animal experiment
