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粪菌移植治疗溃疡性结肠炎汇总分析 被引量:10

A pooling analysis of fecal microbiota transplantation in treatment of ulcerative colitis
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摘要 研究表明,菌群紊乱引起肠道固有免疫的异常激活可致溃疡性结肠炎(ulcerativecolitis,UC)症状持续反复发作。粪菌移植(fecalmicrobiotatransplantation,FMT)通过将健康人粪便中的功能菌群植入患者消化道内来重建肠道菌群,恢复肠道功能。目前FMT对UC治疗有效率尚无系统性评估。本研究汇总分析相关研究,旨在评估FMT在UC应用中的安全性及疗效,进而为临床实践提供依据。
出处 《中国实用内科杂志》 CAS CSCD 北大核心 2015年第9期790-791,共2页 Chinese Journal of Practical Internal Medicine
基金 国家自然科学基金(81300272 81470796) 高等学校博士学科点专项科研基金(20121202110018) 天津市应用基础与前沿技术研究计划(13JCQNJC10600)
关键词 粪菌移植 溃疡性结肠炎 难辨梭状芽孢杆菌 Fecal microbiota transplantation Ulcerative colitis Clostridium difficile
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参考文献11

  • 1Kunde S, Pham A, Bonczyk S, et al. Safety, tolerability, and clinical response after fecal transplantation in children and young adults with ulcerative colitis[J].J Pediatr Gastroenterol Nutr, 2013, 56 (6):597- 601.
  • 2Moayyedi P Surette M, Wolfe M, et al. A randomized, placebo controlled trial of fecal microbiota therapy in active ulcerative colitis [J]. Gastroenterolog 2014, 146(5 ) :S- 159.
  • 3Angelberger S, Reinisch W, Makristathis A, et al. Temporal bacterial community dynamics vary among ulcerative colitis patients after fecal microbiota transplantation[J]. Am J Gastroenterol, 2013, 10g (10):1620-1630.
  • 4Kump PK, Grochenig HP, Lackner S, et al. Alteration of intestinal dysbiosis by fecal microbiota transplantation does not induce remission in patients with chronic active ulcerative colitis[J]. Inflamm Bowel Dis, 2013, 19(10):2155-2165.
  • 5Colman RJ, Rubin DT. Fecal microbiota transplantation as therapy for inflammatory bowel disease: A systematic review and meta-analysis[J]. J Crohns Colitis, 2014, 8 (12): 1569-1581.
  • 6De Leon LM, Watson JB, Kelly CR. Transient flare of ulcerative colitis after fecal microbiota transplantation for recurrent Clostridium difficile infection[J]. Clin Gastroenterol Hepatol, 2013, 11 (8):1036-1038.
  • 7Brace C, Gloor GB, Ropeleski M et al. Microbial composition analysis of Clostridium difficile infections in an ulcerative colitis patient treated with multiple fecal microbiota transplantations[J]. J Crohns Colitis, 2014, 8 (9):1133-1137.
  • 8Libertucci J, Whelan FJ, Moayyedi P, et al. Investigating the microhiome pre and post fecal microbiota therapy from active ulcerative colitis patients in a randomized placebo controlled trial[J]. Gastroenterology, 2014, 146(5):S-902.
  • 9刘嫦钦,吴维,邬瑞金,汤茂春,邱骅婧,陈腾飞,杨雪华,刘占举.健康者粪便微生物移植治疗溃疡性结肠炎一例[J].中华消化杂志,2013,33(12):873-873. 被引量:3
  • 10Gough E, Shaikh H, Manges AR. Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection [J]. Clin Infect Dis, 2011, 53 (10) :994- 1002.

二级参考文献7

  • 1Martinez C, Antolin M, Santos J, et al. Unstable composition of the fecal microbiota in ulcerative colitis during clinical remission. Am J Gastroenterol, 2008,103: 643-648.
  • 2Rowan F, Docherty NG, Murphy M, et al. Desulfovibrio bacterial species are increased in ulcerative colitis. Dis Colon Rectum, 2010,53 : 1530-1536.
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  • 4Borody TJ, Campbell J. Fecal microbiota transplantation: current status and future directions. Expert Rev Gastroenterol Hepatol, 2011,5: 653-655.
  • 5Kahn SA, Gorawara-Bhat R, Rubin DT. Fecal bacteriotherapy for ulcerative colitis: patients are ready, are we? Inflamm Bowel Dis, 2012,18 : 676-684.
  • 6Borody TJ, George L, Andrews P, et al. Bowel-flora alteration: a potential cure for inflammatory bowel disease and irritable bowel syndrome? Med J Aust, 1989,150: 604.
  • 7Borody TJ, Warren EF, Leis S, et al. Treatment of ulcerative colitis using fecal bacteriotherapy. J Clin Gastroenterol, 2003,37:42-47.

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